Datasheet

Safety Data Sheet (1907/2006/EC)
Material: 60008010 ELASTOSIL® N10 TRANSPARENT
Version: 3.0 (GB) Date of print: 22.08.2014 Date of last alteration: 13.02.2014
Page: 7/10
Product details:
Route of exposure Result/Effect Species/Test system Source
dermal not sensitizing guinea-pig; Bühler test report
OECD 406
11.1.5 Germ cell mutagenicity
Assessment:
For this endpoint no toxicological test data is available for the whole product.
11.1.6 Carcinogenicity
Assessment:
For this endpoint no toxicological test data is available for the whole product.
11.1.7 Reproductive toxicity
Assessment:
For this endpoint no toxicological test data is available for the whole product.
11.1.8 Specific target organ toxicity (single exposure)
Assessment:
For this endpoint no toxicological test data is available for the whole product.
11.1.9 Specific target organ toxicity (repeated exposure)
Assessment:
For this endpoint no toxicological test data is available for the whole product.
11.1.10 Aspiration hazard
Assessment:
For this endpoint no toxicological test data is available for the whole product.
11.1.11 Further toxicological information
Hydrolysis product / Impurity: 2-Butanone oxime (MEKO, CAS 96-29-7) is a dermal sensitizer and strongly irritating to the eyes. 2-
Butanone oxime is rapidly absorbed from the gastrointestinal tract, upon contact with skin and after inhalation. After oral exposure
of rats to MEKO in an acute neurotoxicity study, transient motor incoordination effects were observed. Prolonged exposure of
animals led to damages of the olfactory epithelium and to an increase in the incidence of corneal dystrophy and opacities.
Systemic effects in repeated dose studies (oral, inhalative) were hemolytic anemia and compensatory and extramedullary
hematopoiesis as well as hemosiderosis in spleen and liver and increased levels of methemoglobin. In several of these studies,
the effects were reversible. Gross histopathologic alterations were seen in spleen, lung and kidney. After chronic inhalative
exposure to high vapor concentrations an increased incidence of hepatocellular carcinomas and adenomas was observed
predominantly in male rats and mice. The significance of these results to human users has not been assessed.
SECTION 12: Ecological information 12.
12.1
Toxicity
Assessment:
According to past experience toxicity to fish is improbable. According to current knowledge adverse effects on water purification
plants are not expected.
12.2
Persistence and degradability
Assessment:
Biologically not degradable.
12.3
Bioaccumulative potential
Assessment:
Bioaccumulation is not expected to occur.