User`s guide

Table of Contents
Voyager Biospectrometry Workstation User’s Guide v
Chapter 3 Preparing Samples
3.1 Preparing Samples ................................................................. 3-2
3.1.1 Selecting a Matrix .................................................................. 3-3
3.1.2 Preparing Matrix .................................................................... 3-4
3.1.3 Matrix Information .................................................................. 3-6
3.1.4 Preparing Sample .................................................................3-17
3.1.5 Sample Cleanup ...................................................................3-19
3.1.5.1 Washing ...............................................................3-20
3.1.5.2 Drop Dialysis (Floating Membrane) ......................3-21
3.1.5.3 Cation Exchange ..................................................3-23
3.1.5.4 ZipTips
®
................................................................3-24
3.1.6 Mixing Sample and Matrix (Dried Droplet Application) ...........3-26
3.2 Loading Samples on Sample Plates
........................................... 3-28
3.2.1 Overview ...............................................................................3-28
3.2.2 Loading Samples (Dried Droplet Application) ........................3-31
3.2.3 Loading Samples (Thin Layer Application) ............................3-33
3.2.4 Examining Crystals on Sample Plates ...................................3-34
3.3 Cleaning Sample Plates
.......................................................... 3-36
3.4 Loading Sample Plates in the Mass Spectrometer
......................... 3-39
3.4.1 Ejecting the Sample Holder ...................................................3-41
3.4.2 Loading Sample Plates .........................................................3-42
3.5 Sample Plate Types Supported
................................................. 3-47
3.5.1 Sample Plates Types and Applications ..................................3-48
3.5.2 Editable-Configuration Plate (.PLT) Types
Provided with the System ......................................................3-50
3.5.3 Guidelines for
Defining Custom Plate Types ................................................3-52
3.5.4 Adjusting the Laser Position for a Custom .PLT File ..............3-63