SDS

Quick-FDS [18133-12185-25785-010708] - 2017-08-23 - 03:23:06
Product:
FORANE® 404A
Page: 6 / 10
SDS No.: 001741-001 (Version 1.3) Date 22.08.2017 (Cancel and replace : 19.06.2017)
ARKEMA 420 rue d’Estienne d'Orves - 92700 Colombes – FRANCE
In vitro
1,1,1 TRIFLUOROETHANE :
Ames test: negative (Method: OECD Test Guideline 471)
In vitro chromosomal abnormality test on human lymphocytes: negative
PENTAFLUOROETHANE :
Ames test: negative (Method: OECD Test Guideline 471)
In vitro test for chromosomal abnormalities on CHO cells: negative (Method: OECD Test Guideline 473)
In vitro chromosomal abnormality test on human lymphocytes: negative (Method: OECD Test Guideline
476)
1,1,1,2-TETRAFLUOROETHANE :
Ames test in vitro: Inactive (Method: OECD Test Guideline 471)
In vitro chromosomal abnormality test on human lymphocytes: Inactive (Method: OECD Test Guideline
473)
In vitro gene mutations test on mammalian cells: Inactive
In vivo
1,1,1 TRIFLUOROETHANE :
Micronucleus test in vivo mouse: negative
PENTAFLUOROETHANE :
Micronucleus test in vivo mouse: negative (Method: OECD Test Guideline 474)
1,1,1,2-TETRAFLUOROETHANE :
Micronucleus test in vivo mouse: Inactive (Method: OECD Test Guideline 474)
DNA repair test on rats hepatocytes: Inactive
Carcinogenicity: Based on the available data, the substance is not suspected of having carcinogenic potential
1,1,1 TRIFLUOROETHANE :
• In animals :
According to available experimental data:
No effect maximum concentration
(Rat, 1 year, By oral route)
1,1,1,2-TETRAFLUOROETHANE :
• In animals :
Absence of carcinogenic effects (Rat, 2 years, By inhalation)
No Observed Adverse Effect Level (NOAEL): 10,000 ppm
Absence of carcinogenic effects (Rat, 1 year, By oral route)
No Observed Adverse Effect Level (NOAEL): 300 mg/kg bw/day
Reproductive toxicity:
Fertility: Based on the available information, it is not possible to conclude on the hasard potential of this
mixture.
1,1,1 TRIFLUOROETHANE :
No data available.
PENTAFLUOROETHANE :
No data available.
1,1,1,2-TETRAFLUOROETHANE :
• In animals : Two-generation study
NOAEL ( Parental toxicity ): 50,000 ppm
NOAEL ( Fertility ): 50,000 ppm
NOAEL ( Developmental Toxicity ): 50000 ppm
(rat, By inhalation)
Foetal development: Based on the available data, the substance is not suspected of having developmental toxicity
potential.
1,1,1 TRIFLUOROETHANE :
• In animals : NOAEL ( Developmental Toxicity ): 137 mg/l
NOAEL ( Maternal Toxicity ): 137 mg/l
(Method: OECD Test Guideline 414, rat, rabbit, By inhalation)
PENTAFLUOROETHANE :
• In animals : Absence of toxic effects for foetal development.
NOAEL ( Developmental Toxicity ): 245 mg/l
NOAEL ( Maternal Toxicity ): 245 mg/l
(Method: OECD Test Guideline 414, rat, rabbit, By inhalation)
1,1,1,2-TETRAFLUOROETHANE :
• In animals : Absence of toxic effects for foetal development.
NOAEL ( Developmental Toxicity ): 40,000 ppm
NOAEL ( Maternal Toxicity ): 2,500 ppm
(Method: OECD Test Guideline 414, Rabbit, By inhalation)
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