SDS

Safety Data Sheet
Material Name: COAL TAR CREOSOTE (PRESSURE APPLICATIONS)
SDS ID: 00227842
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Page 13 of 18
Issue date: 2015-12-30 Revision 2.6
Print date: 2016-01-06
exposure period. Creosote deposition in the nose and upper respiratory tract produced acute and chronic
inflammation which decreased along the tract toward the lungs. The lung changes were limited to pigment
deposition characterized as trace level in severity. There were no lung inflammatory changes or lesions of
any type. One high-dose and one mid-dose animal showed signs of myocardial degeneration. Thyroid
changes (follicular cell hypertrophy) were noted in creosote-exposed animals; this condition was
reversible following termination of exposure for 6 weeks however trace levels of pigment remained in the
lungs and nose along with cyst formation in the nose. No changes indicative of heart damage were
observed in any animal following the recovery period. At the end of the exposure period and at the end of
the recovery period, animals were evaluated by a veterinary ophthalmologist for signs of eye damage due
to airborne creosote. No test material related eye changes were recorded. The NOAEL level in this study
was 5.4 mg/m3.
Dermal – No systemic effects following single high-level exposure.
Dermal – 90 daily applications of P1/P13 creosote to their skin of rats at doses of 400, 40 or 4 mg/kg/day
for 90 days produced essentially no effect other than slight skin irritation. All parameters for toxicity
including ophthalmoscopic examination appeared to be completely unaffected by dermal creosote
exposure.
In addition to containing information about the product as a whole, this data sheet also contains
information about individual components of the product. Information of this nature may not have been
derived from studies or data relating to this product and/or may have been derived from studies or data
that did not involve human exposure and involved animal exposure only.
A neoplastic effect was reported in mice with subcutaneous injection of 46 mg/kg of diphenyl. Some
polycyclic aromatic hydrocarbons (PAHs), found in coal tar complex substances, have been reported to
cause lung and skin cancer in humans under conditions of poor personal hygiene, prolonged/repeated
contact, and exposure to sunlight. The National Toxicology Program (NTP) and IARC have
independently classified various PAH compounds present in coal tar substances as reasonably anticipated
to be human carcinogens (NTP), probably carcinogenic to humans (IARC Group 2A), possibly
carcinogenic to humans (IARC Group 2B), and not classifiable as to carcinogenicity to humans (IARC
Group 3). The cancers reported in the studies upon which IARC based its conclusions involved lung, skin,
liver, stomach, kidney and blood cancers in animals. Based on the results of animal experiments PAHs
may cause injury to the liver, kidneys, lungs, blood and lymph systems. Some PAH's have also been
associated with impaired fertility, heritable genetic damage and birth defects in mice.
Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity
Very toxic to aquatic life. Toxic to aquatic life with long lasting effects.
Component Analysis - Aquatic Toxicity
COAL TAR
CREOSOTE
8001-58-9