SDS

Safety Data Sheet
Material Name: COAL TAR CREOSOTE (PRESSURE APPLICATIONS)
SDS ID: 00227842
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Page 12 of 18
Issue date: 2015-12-30 Revision 2.6
Print date: 2016-01-06
Germ Cell Mutagenicity
Did not exhibit a dominant lethal effect in testing with male rats administered orally at the maximum dose
of 725 mg/kg for 5 days and is considered negative for the induction of a germ cell mutation effect.
Tumorigenic Data
No data available
Reproductive Toxicity
When tested in a 2-generation reproductive toxicity study in rats, no adverse reproductive or
developmental effects were seen in the absence of paternal systemic toxicity. P1/P13 creosote is not
considered a reproductive toxin. When tested in a developmental toxicity study in rats damage to the
embryo or the fetus did not occur at dose levels that did not harm the mother. P1/P13 creosote is not
considered a developmental toxin.
Specific Target Organ Toxicity - Single Exposure
respiratory system
Specific Target Organ Toxicity - Repeated Exposure
No data available.
Aspiration hazard
No data available.
Medical Conditions Aggravated by Exposure
respiratory disorders, skin disorders
Additional Data
This product is coal tar creosote. Volume 35 of the IARC monograph states that there is limited evidence
that coal tar derived creosotes are carcinogenic in humans and sufficient evidence for the carcinogenicity
of creosote in experimental animals (Group 2A). IARC’s evaluation of the effects of coal tar creosote in
humans is based on older occupational studies in the wood-preserving and construction industries. When
applied to the skin of mice in experimental studies, creosote produced skin tumors and in one study
produced lung tumors.
Today, with the use of engineering controls and personal protective equipment, occupational exposure to
creosote components is expected to be below permissible exposure limits (measured as
CTPVs). Recently, the largest health effects study to date of workers employed in creosote wood treating
plants (2,179 employees at eleven plants from 1979-2001) conducted by Dr. Otto Wong, found no
evidence supporting an increased risk of cancer death as a result of exposure to creosote. The NOAEL for
rats in a 13-week subchronic inhalation study was 5.4 mg/m3. The NOAEL for female rats in a 90-day
subchronic dermal study was greater than 400 mg/mg, and the NOAEL for male rats was 40 mg/kg.
Based on Buehler dermal sensitization testing, creosote is not considered to be a dermal sensitizing
agent. Prolonged or frequently repeated skin contact may cause allergic reactions in some individuals.
Prolonged and repeated skin exposure over many years in the absence of recommended hygiene practices
may lead to changes in skin pigmentation, benign skin growth, and in some cases, result in skin cancer.
Inhalation – 90 day repeated exposure - Rats exposed to P1/P13 creosote for 6 hours/day 5 days/week for
13 weeks to 106, 59 and 5.4 mg/m3 showed weight loss or weight gain suppression in the top two
exposure groups and staining of the animals’ respiratory tract and lungs immediately after the 90-day