SDS

Safety Data Sheet
Material Name: COAL TAR CREOSOTE (PRESSURE APPLICATIONS)
SDS ID: 00227842
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Page 11 of 18
Issue date: 2015-12-30 Revision 2.6
Print date: 2016-01-06
Ingestion
gastrointestinal irritation, bloating
Acute and Chronic Toxicity
Component Analysis - LD50/LC50
The components of this material have been reviewed in various sources and no selected endpoints have
been identified
Product Toxicity Data
Product Analysis LD/LC 50 Toxicity Values
Oral LD50:
Rat 2197 mg/kg
Dermal LD50:
Rabbit >2000 mg/kg
Inhalation LC50:
Rat >5 mg/L 4 h
Immediate Effects
respiratory tract irritation, mild skin irritation, eye irritation, thermal burns from heated material
Delayed Effects
skin cancer
Irritation/Corrosivity Data
0.5 ml/4 hour(s) skin-rabbit mild (Draize Score-1.8/8.0); 0.1 ml eyes-rabbit mild (Draize Score-
7.0/110.0), Rabbit Eye Irritation: No corneal changes; conjunctival changes all reversed by 8-21 days post
treatment. Max irritation score = 7.0/110, Rabbit Dermal Irritation: Slight-to-well-defined erythema and
very slight-to slight edema cleared by day 14, PSI = 1.8/8.0
Respiratory Sensitization
No data available.
Dermal Sensitization
Negative dermal sensitization in guinea pigs.
Component Carcinogenicity
COAL TAR
CREOSOTE
8001-58-9
ACGIH:
A1 - Confirmed Human Carcinogen (related to Pitch, coal tar, high-temperature)
IARC:
Monograph 100F [2012]; Supplement 7 [1987]; Monograph 35 [1985] (related
to Pitch, coal tar, high-temperature) (Group 1 (carcinogenic to humans))
NTP:
Known Human Carcinogen (related to Pitch, coal tar, high-temperature)
NIOSH:
potential occupational carcinogen
In a 6 month mouse skin cancer initiation-promotion study, undiluted creosote or a 1% or 50% creosote
suspension was applied daily for two weeks followed by six months of twice-weekly
applications. Creosote was tested as a tumor initiator with TPA as a promotor, as a promoter with DMBA
as an initiator, and as both an initiator and a promoter. Repeated applications of creosote produced skin
irritation and acted as an initiator, a promoter and a complete carcinogen.