Technical data
34 Agilent 1290 Infinity LC System Manual and Quick Reference
2 The Agilent 1290 Infinity LC System - Product Description
System Components
The Agilent 1290 Infinity Thermostatted Column Compartment
The Agilent 1290 Infinity Thermostatted Column Compartment (TCC) controls 
the temperature between 10 °C below ambient and up to 100 °C at 2.5 ml/min 
and 80 °C at up to 5 ml/min, respectively. The temperature stability 
specification is ± 0.05 °C and the accuracy specification ±0.5 °C (with 
calibration)
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. This is achieved by a combination of conduction from contact 
with the thermostat vanes, still-air temperature in the column environment 
and most importantly by pre-heating (or cooling) the mobile phase by passing 
it through a heat exchanger before entering the column. There are two 
independent temperature zones in each TCC which can work together for long 
columns up to 300 mm length or work at different temperatures for short 
columns of 100 mm length or less.
The module comes with a 1.6 µl low dispersion heat exchanger and each valve 
kit contains additional low dispersion heat exchangers for each column. The 
low dispersion heat exchangers, up to 4, can be mounted flexibly inside the 
TCC. For conventional HPLC operation, 3 µl and 6 µl built-in heat exchangers 
are also available.
Each TCC can accommodate one internal valve drive to facilitate valve 
switching applications from simple switching between two columns to 
automatic column regeneration, sample preparation or column back-flushing. 
Each valve head comes as a complete kit containing all required capillaries, 
additional low dispersion heat exchangers and other parts.
The switching valves have exceptional ease-of-use and flexibility when making 
connections to the valve: When pressed, the drive unit of the Quick Change 
Valve slides forward for easy access (see Figure 19 on page 35 left). Alternative 
valve heads can be interchanged by the user on the drive mechanism for 
different applications (see Figure 19 on page 35 right). Note the RFID tag on 
top of valve head.
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All specifications are valid for distilled water at ambient temperature of 25 °C, setpoint at 40 °C 
and a flow range from 0.2 to 5 ml/min.










