Specification
Version: 1.0 
Revision Date: 03/28/2016 
000000023904 
14/19 
1,2,4-Trimethylbenzene  LC 50 (Fathead minnow (Pimephales promelas), 96 h): 7.19 - 8.28 mg/l 
Mortality 
1,3,5-Trimethylbenzene  LC 50 (Goldfish (Carassius auratus), 96 h): 9.89 - 15.05 mg/l Mortality 
Aquatic Invertebrates 
Product: 
No data available. 
Specified substance(s): 
1,2,4-Trimethylbenzene  LC 50 (Scud (Elasmopus pectinicrus), 24 h): 4.89 - 5.62 mg/l Mortality 
1,3,5-Trimethylbenzene  EC 50 (Water flea (Daphnia magna), 24 h): 50 mg/l Intoxication 
Chronic hazards to the aquatic environment: 
Fish 
Product: 
No data available. 
Specified substance(s): 
Titanium dioxide  ED 0 (Phoxinus phoxinus, 30 d): >= 1,000 mg/l Experimental result, 
Supporting study 
LC 10 (Oncorhynchus mykiss, 28 d): 0.981 mg/l Read-across from 
supporting substance (structural analogue or surrogate), Supporting study 
LC 50 (Oncorhynchus mykiss, 28 d): 7.31 mg/l Read-across from supporting 
substance (structural analogue or surrogate), Supporting study 
LC 1 (Oncorhynchus mykiss, 28 d): 0.191 mg/l Read-across from supporting 
substance (structural analogue or surrogate), Supporting study 
LC 0 (Coregonus autumnalis migratorius G., 30 d): 3 mg/l Experimental 
result, Supporting study 
Heavy aromatic naphtha  NOAEL (Oncorhynchus mykiss, 28 d): 0.098 mg/l QSAR QSAR, Key study 
Aromatic petroleum 
distillates 
LL 50 (Pimephales promelas, 14 d): 5.2 mg/l Experimental result, Supporting 
study 
EC 50 (Daphnia magna, 21 d): 10 mg/l Other, Key study 
NOAEL (Pimephales promelas, 14 d): 2.6 mg/l Experimental result, 
Supporting study 
NOAEL (Daphnia magna, 21 d): 2.6 mg/l Other, Key study 
Aluminum oxide  NOAEL (Pimephales promelas, 28 d): 4.7 mg/l Experimental result, Weight 
of Evidence study 
IC 25 (Pimephales promelas, 7 d): 11.59 mg/l Experimental result, Weight of 
Evidence study 
LOAEL (Salvelinus fontinalis, 60 d): 0.35 mg/l Experimental result, Weight of 
Evidence study 
NOAEL (Pimephales promelas, 7 d): 0.4 mg/l Read-across based on 
grouping of substances (category approach), Weight of Evidence study 
NOAEL (Pimephales promelas, 7 d): >= 0.831 mg/l Experimental result, 
Weight of Evidence study 
Aquatic Invertebrates 
Product: 
No data available. 
Toxicity to Aquatic Plants 
Product: 
No data available. 










