SDS

Xylene
Section 10. Stability and reactivity
Hazardous decomposition
products
Conditions to avoid
Avoid all possible sources of ignition (spark or flame). Do not pressurize, cut, weld,
braze, solder, drill, grind or expose containers to heat or sources of ignition. Do not
allow vapor to accumulate in low or confined areas.
Under normal conditions of storage and use, hazardous decomposition products should
not be produced.
The product is stable.
Chemical stability
Reactive or incompatible with the following materials:
oxidizing materials
:
:
:
Incompatible materials
:
Possibility of hazardous
reactions
:
Under normal conditions of storage and use, hazardous reactions will not occur.
Reactivity
:
Not expected to be Explosive, Self-Reactive, Self-Heating, or an Organic Peroxide
under US GHS Definition(s).
Section 11. Toxicological information
Acute toxicity
Xylenes, mixed isomers
LC50 Inhalation Gas.
Cat
9500 ppm
2 hours
LC50 Inhalation Gas.
Rat
5000 ppm
4 hours
LC50 Inhalation Gas.
Rat
6700 ppm
4 hours
LC50 Inhalation Gas.
Rat
6670 ppm
4 hours
LD50 Oral
Mouse
2119 mg/kg
-
LD50 Oral
Rat
4300 mg/kg
-
LD50 Oral
Rat
4300 mg/kg
-
Ethylbenzene
LD50 Dermal
Rabbit
>5000 mg/kg
-
LD50 Oral
Rat
3500 mg/kg
-
Product/ingredient name
Result
Species
Dose
Exposure
Information on toxicological effects
Conclusion/Summary
:
Xylenes, mixed isomers
: Effects from Acute Exposure:
ORAL (LD
50
), Acute: 4,300 mg/kg [Rat].
INHALATION (LC
50
), Acute: 4,550 ppm for four hours [Rat].
DERMAL (LD
50
), Acute: 14,100 uL/kg [Rabbit].
Overexposure to xylene may cause upper respiratory tract irritation, headache, cyanosis,
blood serum changes, CNS damage and narcosis. Effects may be increased by the
use of alcoholic beverages. Evidence of liver and kidney impairment were reported in
workers recovering from a gross over-exposure.
Ethylbenzene
: Effects from Acute Exposure:
ORAL (LD50), Acute: 3,500 mg/kg [Rat].
DERMAL (LD50), Acute: 17,800 uL/kg [Rabbit].
INTRAPERITONEAL (LD50), Acute: 2,624 mg/kg [Rat].
Effects from Prolonged or Repeated Exposure:
Findings from a 2-year inhalation study in rodents conducted by NTP were as follows:
Effects were observed only at the highest exposure level (750 ppm). At this level the
incidence of renal tumors was elevated in male rats (tubular carcinomas) and female
rats (tubular adenomas). Also, the incidence of tumors was elevated in male mice
(alveolar and bronchiolar carcinomas) and female mice (hepatocellular carcinomas).
IARC has classified ethyl benzene as “possibly carcinogenic to humans” (Group 2B).
Studies in laboratory animals indicate some evidence of post-implantation deaths
following high levels of maternal exposure. The relevance of these findings to humans
is not clear at this time. Studies in laboratory animals indicate limited evidence of renal
malformations, resorptions, and developmental delays following high levels of maternal
exposure. The relevance of these findings to humans is not clear at this time. Studies
in laboratory animals indicate some evidence of adverse effects on the liver, kidney,
Date of issue/Date of revision
:
1/30/2015.
Version
:
6
7/13