Safety data sheet

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STANLEYCHALKSMSDS 
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STANLEYCHALKSMSDS
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11.TOXICOLOGICALINFORMATION(Continued)
INGESTION(continued):Repeatedingestionofironcompoundscancausevomiting,diarrhea,pinkurine,blackstool,and
liverorkidneydamage.Repeatedingestionofironcompoundscanalsocausesiderosis,whichisanaccumulationofiron
intissues.
INJECTION
:Theseproductsdonotposeahazardofinjection.
HEALTH EFFECTS OR RISKS FROM EXPOSURE:  An Explanation in Lay Terms
.  In the event of overexposure, the
followingsymptomsmaybeobserved:
ACUTE:Acuteexposuretotheskinandeyescancausemechanicalirritation.Inhalationofdustscancausepulmonary
irritation.
CHRONIC: Repeated inhalationexposuremaycause adverseeffectstotherespiratorysystem. Chronic inhalation may
resultinpulmonaryfibrosis.Thisproductcontainscrystallinesilica,whichisaknownhumancarcinogen.
TARGETORGANS:ACUTE:Skin,eyes,respiratorysystem.CHRONIC:Skin,respiratorysystem.
TOXICITYDATA
:Currently,toxicitydataareavailableforthefollowingcomponentsoftheseproducts:

LIMESTONE/CALCIUMCARBONATE:
TCLo (Inhalation-Rat) 84 mg/m
3
/4 hohrs/40 weeks-
intermittent: Lungs, Thorax, or Respiration: fibrosis
(interstitial);Liver:otherchangesKidney/Ureter/Bladder:
otherchanges
TCLo (Inhalation-Rat) 250 mg/m
3
/2 hours/24 weeks-
intermittent:Lungs,Thorax,orRespiration:fibrosis,focal
(pneumoconiosis)
CARBONBLACK:
LD
50
 (Oral-Rat) > 15,400 mg/kg: Behavioral: somnolence
(generaldepressedactivity)
LD
50
(Skin-Rabbit)>3gm/kg
TDLo (Intravenous-Rat) 10 mg/kg/2 minutes: Liver:
changesinliverweight;Blood:changesinspleen
TDLo(Intravenous-Rat)10mg/kg/2minutes:Biochemical;
Enzyme inhibition, induction, or change in blood or
tissue levels: hepatic microsomal mixed oxidase
(dealkylation,hydroxylation,etc.)
TDLo (Skin-Rat) 11 gm/kg/4 weeks-intermittent: Blood:
pigmented or nucleated red blood cells;Liver: changes
in liver weight; Nutritional and Gross Metabolic: weight
lossordecreasedweightgain
TDLo (Intratracheal-Rat) 16 mg/kg: Lungs, Thorax, or
Respiration: other changes; Biochemical: Metabolism
(Intermediary): effect on inflammation or mediation of
inflammation
TDLo (Intratracheal-Rat) 15 mg/kg: Lungs, Thorax, or
Respiration: other changes; Biochemical: Enzyme
inhibition,induction,orchangeinbloodortissuelevels:
cytochrome oxidases (including oxidative
phosphorylation)
TDLo (Intratracheal-Rat) 10 mg/kg: Lungs, Thorax, or
Respiration: sputum; Biochemical: Metabolism
(Intermediary): other proteins, effectoninflammation or
mediationofinflammation
TDLo (Intratracheal-Mouse) 20 mg/kg: Lungs, Thorax, or
Respiration: other changes; Biochemical: Metabolism
(Intermediary): effect on inflammation or mediation of
inflammation
TDLo (Intratracheal-Mouse) 20 mg/kg/4 days-intermittent:
Lungs, Thorax, or Respiration: sputum; Immunological
IncludingAllergic:increaseincellularimmuneresponse;
Biochemical: Metabolism (Intermediary): effect on
inflammationormediationofinflammation
TDLo (Parenteral-Mouse) 36 µg/kg/3 days-intermittent:
Immunological Including Allergic: increase in humoral
immuneresponse
TCLo (Inhalation-Rat) 7 mg/m
3
: Lungs, Thorax, or
Respiration: other changes; Biochemical: Metabolism
(Intermediary): effect on inflammation or mediation of
inflammation
TCLo(Inhalation-Rat)1.66mg/m
3
/7hours:Lungs,Thorax,
or Respiration: sputum; Blood: changes in leukocyte
(WBC) count; Biochemical: Metabolism (Intermediary):
effectoninflammationormediationofinflammation
TCLo (Inhalation-Rat) 50 mg/m
3
: Sense Organs and
Special Senses (Olfaction): effect, not otherwise
specified;Biochemical:Metabolism(Intermediary):effect
oninflammationormediationofinflammation
TCLo (Inhalation-Rat) 50 mg/m
3
/6 hours/90 days-
intermittent: Lungs, Thorax, or Respiration: other
changes
TCLo (Inhalation-Rat) 1 mg/m
3
/13 weeks-intermittent:
Lungs, Thorax, or Respiration: other changes;
Biochemical: Metabolism (Intermediary): effect on
inflammationormediationofinflammation
TCLo (Inhalation-Rat) 1 mg/m
3
/13 weeks-intermittent:
Lungs,Thorax,or Respiration: otherchanges, changes
in lungweight; Biochemical: Metabolism(Intermediary):
effectoninflammationormediationofinflammation
CARBONBLACK(continued):
TCLo (Inhalation-Rat) 50 mg/m
3
/13 weeks-intermittent:
Lungs, Thorax, or Respiration: other changes;
Biochemical:Metabolism(Intermediary):other
TCLo (Inhalation-Rat) 50 mg/m
3
/13 weeks-intermittent:
Lungs, Thorax, or Respiration: other changes;
Biochemical:Metabolism(Intermediary):other,effecton
inflammationormediationofinflammation
TCLo (Inhalation-Rat) 7 mg/m3/6 hours/13 weeks-
intermittent: Sense Organs and Special Senses
(Olfaction):effect,nototherwisespecified;Biochemical:
Metabolism (Intermediary): effect on inflammation or
mediationofinflammation
TCLo(Inhalation-Mouse)50mg/m
3
/6hours:SenseOrgans
and Special Senses (Olfaction): effect, not otherwise
specified
TCLo (Inhalation-Mouse) 1 mg/m
3
/13 weeks-intermittent:
Lungs, Thorax, or Respiration: other changes;
Biochemical: Metabolism (Intermediary): effect on
inflammationormediationofinflammation
TCLo (Inhalation-Mouse) 1 mg/m
3
/13 weeks-intermittent:
Lungs, Thorax, or Respiration: other changes; Lungs,
Thorax, or Respiration: changes in lung weight;
Biochemical: Metabolism (Intermediary): effect on
inflammationormediationofinflammation
TCLo (Inhalation-Mouse) 7 mg/m
3
/6 hours/13 weeks-
intermittent: Sense Organs and Special Senses
(Olfaction):effect,nototherwisespecified;Biochemical:
Metabolism (Intermediary): effect on inflammation or
mediationofinflammation
TCLo(Inhalation-Hamster) 7mg/m
3
/13weeks-intermittent:
Lungs, Thorax, or Respiration: other changes;
Biochemical: Metabolism (Intermediary): effect on
inflammationormediationofinflammation
TCLo (Inhalation-Hamster) 50 mg/m
3
/6 hours/13 weeks-
intermittent: Sense Organs and Special Senses
(Olfaction):effect,nototherwisespecified
CRYSTALLINESILICA,CRYSTALLINE-QUARTZ:
LCLo(Inhalation-Human)300mg/m
3
/10years-intermittent:
Systemiceffects
TCLo (Inhalation-Human) 16 mppcf/8 hours/17.9 years-
intermittent:Pulmonarysystemeffects
TCLo (Inhalation-Rat) 50 mg/m
3
/6 hours/71 weeks-
intermittent:Carcinogeniceffects
TCLo (Inhalation-Rat) 80 mg/m
3
/26 weeks-intermittent:
Lungs, Thorax, or Respiration: fibrosis, focal
(pneumoconiosis); Blood: changes in spleen;
Immunological IncludingAllergic: decreaseincellular
immune
TCLo (Inhalation-Rat) 108 mg/m
3
/6 hours/3 days-
intermittent: Biochemical: Enzyme inhibition,
induction, or change in blood or tissue levels:
phosphatases, Enzyme inhibition, induction, or
change in blood or tissue levels: other
oxidoreductases, Metabolism (Intermediary): other
proteins
TCLo (Inhalation-Rat) 58 mg/m
3
/13 weeks-intermittent:
Lungs, Thorax, or Respiration: other changes;
Endocrine: changes in thymus weight; Blood:
changesinleukocyte(WBC)count
TCLo (Inhalation-Mouse) 1475 µg/m
3
/8 hours/21 weeks-
intermittent: Lungs, Thorax, or Respiration: other
changes
TCLo (Inhalation-Mouse) 4932 µg/m
3
/24 hours/39 weeks-
continuous: Endocrine: changes in spleen weight;
ImmunologicalIncludingAllergic:decreaseinhumoral
immuneresponse
TCLo (Inhalation-Guinea Pig) 28 mg/m
3
/3 weeks-
continuous: Lungs, Thorax, or Respiration: other
changes, changes in lung weight; Biochemical:
Enzyme inhibition, induction, or change in blood or
tissuelevels:other
CRYSTALLINE SILICA, CRYSTALLINE-QUARTZ
(continued):
TDLo(Intraperitoneal-Rat)45mg/kg:Carcinogeniceffects
TDLo (Intratracheal-Rat) 90 mg/kg: Equivocal tumorigenic
agent
TDLo(Intratracheal-Rat)90mg/kg:AR
TDLo(Intratracheal-Rat)111mg/kg:Carcinogeniceffects
TDLo(Intratracheal-Rat)111mg/kg:AR
TDLo(Intratracheal-Rat)100mg/kg/19weeks-intermittent:
Tumorigenic: equivocaltumorigenic agentbyRTECS
criteria;Lungs,Thorax,orRespiration:tumors
TDLo(Intrapleural-Rat)90mg/kg:Carcinogeniceffects
TDLo (Intrapleural-Hamster) 83 mg/kg: Tumorigenic:
neoplastic by RTECS criteria, tumors at site of
application
TDLo(Implant-Rat)900mg/kg:Neoplasticeffects
TDLo (Implant-Mouse) 4000 mg/kg: Tumorigenic:
equivocal tumorigenic agent by RTECS criteria;
Kidney,Ureter,Bladder:tumors
TDLo(Implant-Mouse)4000mg/kg:Equivocaltumorigenic
agent
TDLo(Intravenous-Rat)90mg/kg:Tumorigenic:equivocal
tumorigenic agent by RTECS criteria; Blood:
lymphoma,includingHodgkin'sdisease
TD (Intraperitoneal-Rat) 90 mg/kg/4 weeks-intermittent:
Equivocaltumorigenicagent
TD (Intraperitoneal-Rat) 450 mg/kg/4 weeks-intermittent:
Neoplasticeffects
TD(Implant-Rat)4554mg/kg:Equivocaltumorigenicagent
TD (Intrapleural-Rat) 200 mg/kg: Equivocal tumorigenic
agent
TD(Intrapleural-Rat)100mg/kg:Carcinogeniceffects
TD(Intrapleural-Rat)100mg/kg:Neoplasticeffects
TD (Intrapleural-Rat) 100 mg/kg: Tumorigenic: equivocal
tumorigenic agentbyRTECScriteria; Lungs,Thorax,
or Respiration: fibrosis, focal (pneumoconiosis),
tumors
LDLo(Intravenous-Rat)90mg/kg
LDLo(Intratracheal-Rat)200mg/kg
LDLo(Intravenous-Mouse)40mg/kg
LDLo(Intravenous-Dog,adult)20mg/kg
Micronucleustest(Human-Lung)40µg/cm
2

Micronucleustest(Hamster-Lung)160µg/cm
2
HEMATITE/IRONOXIDE:
TDLo (Intratracheal-Rat) 12 mg/kg: Lungs, Thorax, or
Respiration: other changes; Biochemical: Enzyme
inhibition,induction,orchangeinbloodortissuelevels:
multipleenzymeeffects
TCLo (Inhalation-Rat) 3900 mg/m
3
/6 hours/68 weeks-
intermittent: Lungs, Thorax, or Respiration: fibrosis
(interstitial)
TCLo (Inhalation-Dog) 3900 mg/m
3
/6 hours/68 weeks-
intermittent: Lungs, Thorax, or Respiration: fibrosis
(interstitial)
MAGNESIUMCARBONATE:
LD
50
(Oral-Rat)7000mg/kg
LD
50
(Oral-Mouse)8000mg/kg
LD
50
(Intraperitoneal-Mouse)1033mg/kg
TCLo (Inhalation-Rat) 76 mg/m
3
/4 hours: Cardiac: pulse
rateincrease,withoutfallinBP;Liver:liverfunctiontests
impaired; Kidney/Ureter/Bladder:otherchangesinurine
composition
TCLo (Inhalation-Rat) 76 mg/m
3
/4 hours: Blood: changes
in serum composition (e.g. TP, bilirubin, cholesterol);
Biochemical:Enzyme inhibition, induction, or change in
bloodortissuelevels:phosphatases
TDLo (Unreported-Mammal-Species Unspecified) 18,000
mg/kg/7 days-intermittent: Gastrointestinal: other
changes;RelatedtoChronicData:death
