SDS

Safety Data Sheet
LUPRANATEM20 ISO
Revision date : 2015/10/05
Page: 9/15
Version: 5.2
(30089687/SDS_GEN_US/EN)
An aerosol was tested.
Dermal
Information on: Diphenylmethane-4,4'-diisocyanate (MDI)
Type of value: LD50
Species: rabbit (male/female)
Value: > 9,400 mg/kg
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Assessment other acute effects
Assessment of STOT single:
Causes temporary irritation of the respiratory tract.
Irritation / corrosion
Assessment of irritating effects: Irritating to eyes, respiratory system and skin. Skin contact may
result in dermatitis, either irritative or allergic.
Skin
Information on: Diphenylmethane-4,4'-diisocyanate (MDI)
Species: rabbit
Result: Irritating.
Method: Draize test
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Eye
Information on: Diphenylmethane-4,4'-diisocyanate (MDI)
Species: rabbit
Result: Irritating.
Method: Draize test
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Sensitization
Assessment of sensitization: Sensitization after skin contact possible. The substance may cause
sensitization of the respiratory tract. As a result of previous repeated overexposures or a single large
dose, certain individuals will develop isocyanate sensitization (chemical asthma) which will cause
them to react to a later exposure to isocyanate at levels well below the PEL/TLV. These symptoms,
which include chest tightness, wheezing, cough, shortness of breath, or asthmatic attack, could be
immediate or delayed up to several hours after exposure. Similar to many non-specific asthmatic
responses, there are reports that once sensitized an individual can experience these symptoms upon
exposure to dust, cold air, or other irritants. This increased lung sensitivity can persist for weeks and
in severe cases for several years. Chronic overexposure to isocyanates has also been reported to
cause lung damage, including a decrease in lung function, which may be permanent. Prolonged
contact can cause reddening, swelling, rash, scaling, or blistering. In those who have developed a
skin sensitization, these symptoms can develop as a result of contact with very small amounts of
liquid material, or even as a result of vapour-only exposure. Animal tests indicate that skin contact
may play a role in causing respiratory sensitization.
Information on: Diphenylmethane-4,4'-diisocyanate (MDI)
Buehler test
Species: guinea pig
Result: sensitizing
Mouse Local Lymph Node Assay (LLNA)
Species: mouse