SDS
Safety Data Sheet
LUPRANATEM20 ISO
Revision date : 2015/10/05
Page: 11/15
Version: 5.2
(30089687/SDS_GEN_US/EN)
Assessment of carcinogenicity: A carcinogenic potential cannot be excluded after prolonged
exposure to severely irritating concentrations. These effects are not relevant to humans at
occupational levels of exposure. IARC Group 3 (not classifiable as to human carcinogenicity).
Information on: Methylenediphenyl diisocyanate
Assessment of carcinogenicity: A carcinogenic potential cannot be excluded after prolonged
exposure to severely irritating concentrations. These effects are not relevant to humans at
occupational levels of exposure. IARC Group 3 (not classifiable as to human carcinogenicity).
Information on: 1,3-Diazetidine-2,4-dione, 1,3-bis[4-[(4- isocyanatophenyl)methyl]phenyl]-
Assessment of carcinogenicity: The product has not been tested. The statement has been derived
from substances/products of a similar structure or composition. A carcinogenic potential cannot be
excluded after prolonged exposure to severely irritating concentrations. These effects are not
relevant to humans at occupational levels of exposure.
Information on: Isocyanic acid, polymethylenepolyphenylene ester, polymer with.alpha.-hydro-
.omega.-hydroxypoly(oxy-1,2-ethanediyl)
Assessment of carcinogenicity: The product has not been tested. The statement has been derived
from substances/products of a similar structure or composition. A carcinogenic potential cannot be
excluded after prolonged exposure to severely irritating concentrations. These effects are not
relevant to humans at occupational levels of exposure.
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Experimental/calculated data: OECD Guideline 453 rat Inhalation 0, 0.2, 1, 6 mg/m3
Result: Lung tumors
Reproductive toxicity
Assessment of reproduction toxicity: Repeated inhalative uptake of the substance did not cause
damage to the reproductive organs.
Teratogenicity
Assessment of teratogenicity: The substance did not cause malformations in animal studies;
however, toxicity to development was observed at high doses that were toxic to the parental animals.
Development
OECD Guideline 414 rat Inhalation 0, 1, 4, 12 mg/m3
NOAEL Mat.: 4 mg/m3
NOAEL Teratog.: 4 mg/m3
The substance did not cause malformations in animal studies; however, toxicity to development was
observed at high doses that were toxic to the parental animals.
Symptoms of Exposure
The most important known symptoms and effects are described in the labelling (see section 2)
and/or in section 11., Eye irritation, skin irritation, allergic symptoms
Medical conditions aggravated by overexposure
The isocyanate component is a respiratory sensitizer. It may cause allergic reaction leading to
asthma-like spasms of the bronchial tubes and difficulty in breathing. Medical supervision of all
employees who handle or come into contact with isocyanates is recommended. Contact may
aggravate pulmonary disorders. Persons with history of respiratory disease or hypersensitivity should
not be exposed to this product. Preemployment and periodic medical examinations with respiratory
function tests (FEV, FVC as a minimum) are suggested. Persons with asthmatic conditions, chronic
bronchitis, other chronic respiratory diseases, recurrent eczema or pulmonary sensitization should
be excluded from working with isocyanates. Once a person is diagnosed as having pulmonary
sensitization (allergic asthma) to isocyanates, further exposure is not recommended.