SDS

Safety Data Sheet
LUPRANATEM20 ISO
Revision date : 2015/10/05
Page: 10/15
Version: 5.2
(30089687/SDS_GEN_US/EN)
Result: sensitizing
Can cause skin sensitization
other
Species: guinea pig
Result: sensitizing
Studies in animals suggest that dermal exposure may lead to pulmonary sensitization. However, the
relevance of this result for humans is unclear.
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Aspiration Hazard
No aspiration hazard expected.
Chronic Toxicity/Effects
Repeated dose toxicity
Assessment of repeated dose toxicity: The substance may cause damage to the olfactory epithelium
after repeated inhalation. The substance may cause damage to the lung after repeated inhalation.
These effects are not relevant to humans at occupational levels of exposure.
Information on: Diphenylmethane-4,4'-diisocyanate (MDI)
Experimental/calculated data: rat (Wistar) (male/female) Inhalation 2 yrs, 6 hr/day 0, 0.2, 1, 6 mg/m3
, olfactory epithelium
NOAEL: 0.2 mg/m3
LOAEL: 1 mg/m3
The substance may cause damage to the olfactory epithelium after repeated inhalation. These
effects are not relevant to humans at occupational levels of exposure. Repeated inhalative uptake of
the substance did not cause damage to the reproductive organs.
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Genetic toxicity
Assessment of mutagenicity: The substance was mutagenic in various bacterial test systems;
however, these results could not be confirmed in tests with mammals.
Information on: Diphenylmethane-4,4'-diisocyanate (MDI)
Genetic toxicity in vitro: OECD Guideline 471 Ames-test Salmonella typhimurium:with and without
metabolic activation ambiguous
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Information on: Diphenylmethane-4,4'-diisocyanate (MDI)
Genetic toxicity in vivo: OECD Guideline 474 Micronucleus assay rat (male) Inhalation negative
No clastogenic effect reported.
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Carcinogenicity
Assessment of carcinogenicity: A carcinogenic potential cannot be excluded after prolonged
exposure to severely irritating concentrations. These effects are not relevant to humans at
occupational levels of exposure. IARC Group 3 (not classifiable as to human carcinogenicity).
Information on: Diphenylmethane-4,4'-diisocyanate (MDI)
Assessment of carcinogenicity: A carcinogenic potential cannot be excluded after prolonged
exposure to severely irritating concentrations. These effects are not relevant to humans at
occupational levels of exposure. IARC Group 3 (not classifiable as to human carcinogenicity).
Information on: P-MDI