SDS

Revision no.: 00
Page 16 of 24
- Carbon black : 2
- Chromium : 1A(Chromium(Ⅵ)compounds(Water insoluble inorganic compounds))
- Ethylbenzene : 2
EU
- Nickel : Carc. 2
- Copper : EPA IRIS: D In carcinogenicity study with rat, tumor was not observed.
- Polyethylene : Fifty rats were implanted with polyethylene. In the polyethylene group, 23 developed
tumors (two of these were unrelated to the implants).
- Boehmite (Al(OH)O) : bauxite and alumina exposure was not associated with increased cancer risk.
- Ethylbenzene : there was clear evidence of carcinogenic activity of ethylbenzene in
rat(male/female)with based on increased incidences of renal tubule neoplasms; increased incidence of
testicular adenoma.
Mutagenicity :
- Graphite : Negative reactions were observed in vitro (Bacterial Reverse Mutation Assay(OECD
Guideline 471, GLP)).
- Fe : In mammalian cell gene mutation assay electrolytic iron, positive carbonyl iron exhibited a
cytotoxic and mutagenic response (OECD TG 476)
- Copper : Negative reactions were observed in both in vitro(Ames test) and in vivo(DNA damage
and/or repair; unscheduled DNA synthesis, micronucleus assay). (GLP)
- Aluminum : Negative reactions were observed in vitro (mammalian cell gene mutation assay with
mouse lymphoma L5178Y cells(OECD TG 476, GLP)) and in vivo (micronucleus assay with rats
(OECD TG 474, GLP)). (Aluminium hydroxide, aluminium chloride, aluminum oxide; read across)
- Lithium hexafluorophosphate(1-) : Negative reactions were observed in both in vivo (Mammalian
Erythrocyte Micronucleus test(OECD Guideline 474)) and in vitro (Bacterial Reverse Mutation
Assay(OECD Guideline 471, GLP)).
- 4-fluoro-1,3-dioxolan-2-one : Positive reactions were observed in vitro (Bacterial Reverse Mutation
Assay(OECD Guideline 471, GLP)) and Negative reactions were observed in vivo (Mammalian
Erythrocyte Micronucleus Test(OECD Guideline 474, GLP)).
- Dimethyl carbonate : Negative reactions were observed in both in vitro (Mammalian Chromosome
Aberration Test (OECD Guideline 473, GLP)) and in vivo (Mammalian Spermatogonial Chromosome
Aberration Test (OECD Guideline 483))
- Polyethylene : Negative reactions were observed in Ames test using Salmonella typhimurium and
Escherichia coli.
- Diiron trioxide : Negative reactions were observed in both in vitro (Mammalian Chromosome
Aberration Test (OECD Guideline 473, GLP)) and in vivo (DNA damage, chromosome aberration and
micronuclei induction test)
- Boehmite (Al(OH)O) : Negative reactions were observed in vitro(mammalian cell gene mutation
assay(OECD TG 476, GLP), Negative reactions were observed in vivo Mammalian Erythrocyte
Micronucleus Test(OECD TG 474, GLP)
- Carbon black : Negative reactions were observed in both in vitro(Bacterial gene mutation test(OECD
TG 471, GLP), Chromosomal aberrations test(OECD TG 476)) and in vivo(DNA damage and/or repair
test).
- Chromium : In vitro mammalian chromosome aberration test, the result of the assay was negative.
(Read across; stainless steel)(OECD TG 473, GLP)
- Lithium carbonate;Lithane : Negative reactions were observed in vitro (Bacterial Reverse Mutation
Assay(OECD Guideline 471, GLP)).
- Ethylbenzene : Negative reactions were observed in in vitro-mammalian chromosome aberration
test(OECD TG 473), mammalian cell gene mutation test (OECD TG 476, GLP) and in vivo-
unscheduled DNA synthesis (UDS) test with mammalian liver cells (OECD TG 486, GLP), mammalian
erythrocyte micronucleus test (OECD TG 474, GLP).