MSDS

Monsanto Company, Lawn & Garden Products
Page: 5 / 8
ROUNDUP® Weed & Grass Killer Super Concentrate Version: 1.0 Effective date: 04/03/2003
Acute inhalation toxicity
Rat, LC50, 4 hours, aerosol:
Practically non-toxic.
FIFRA category IV.
No 4-hr LC50 at the maximum achievable concentration.
Skin sensitization
Guinea pig, Buehler test:
Positive incidence: 0 %
Negative.
No skin sensitization
N-(phosphonomethyl)glycine; {glyphosate}
Mutagenicity
In vitro and in vivo mutagenicity test(s):
Not mutagenic.
Repeated dose toxicity
Rabbit, dermal, 21 days:
NOAEL toxicity: > 5,000 mg/kg body weight/day
Target organs/systems: none
Other effects: none
Rat, oral, 3 months:
NOAEL toxicity: > 20,000 mg/kg diet
Target organs/systems: none
Other effects: none
Carcinogenicity
Mouse, oral, 24 months:
NOEL tumour: > 30,000 mg/kg diet
NOAEL toxicity: ~ 5,000 mg/kg diet
Tumours: none
Target organs/systems: liver
Other effects: decrease of body weight gain, histopathologic effects
Rat, oral, 24 months:
NOEL tumour: > 20,000 mg/kg diet
NOAEL toxicity: ~ 8,000 mg/kg diet
Tumours: none
Target organs/systems: eyes
Other effects: decrease of body weight gain, histopathologic effects
Toxicity to reproduction/fertility
Rat, oral, 3 generations:
NOAEL toxicity: > 30 mg/kg body weight
NOAEL reproduction: > 30 mg/kg body weight
Target organs/systems in parents: none
Other effects in parents: none
Target organs/systems in pups: none
Other effects in pups: none
Developmental toxicity/teratogenicity
Rat, oral, 6 - 19 days of gestation:
NOAEL toxicity: 1,000 mg/kg body weight
NOAEL development: 1,000 mg/kg body weight
Other effects in mother animal: decrease of body weight gain, decrease of survival
Developmental effects: weight loss, post-implantation loss, delayed ossification
Effects on offspring only observed with maternal toxicity.
Rabbit, oral, 6 - 27 days of gestation:
NOAEL toxicity: 175 mg/kg body weight
NOAEL development: 175 mg/kg body weight
Target organs/systems in mother animal: none