MSDS
Monsanto Company, Lawn & Garden Products Page: 6
Roundup® Weed & Grass Killer Concentrate Plus Version: 1.4 Effective date: 06/05/2002
Developmental toxicity/teratogenicity
Rat, oral, 6 - 19 days of gestation:
NOAEL toxicity: 1,000 mg/kg body weight
NOAEL development: 1,000 mg/kg body weight
Other effects in mother animal: decrease of body weight gain, decrease of survival
Developmental effects: weight loss, post-implantation loss, delayed ossification
Effects on offspring only observed with maternal toxicity.
Rabbit, oral, 6 - 27 days of gestation:
NOAEL toxicity: 175 mg/kg body weight
NOAEL development: 175 mg/kg body weight
Target organs/systems in mother animal: none
Other effects in mother animal: decrease of survival
Developmental effects: none
Diquat dibromide
Mutagenicity
Ames test(s):
Not mutagenic without metabolic activation.
Micronucleus test(s):
Not mutagenic.
Dominant lethal test(s):
Not mutagenic.
In vitro chromosomal aberration test(s):
Not mutagenic.
Mammalian cell mutagenicity test(s):
Mutagenic with and without metabolic activation.
In vitro chromosomal aberration test(s):
Mutagenic.
Repeated dose toxicity
Rat, inhalation, 3 weeks:
NOEL toxicity: 0.1 mg/m3
Target organs/systems : lung
Other effects: organ weight change, histopathologic effects, local irritation
Carcinogenicity
Dog, oral, 52 weeks:
NOAEL toxicity: 0.5 mg/kg body weight/day
Target organs/systems : eyes, adrenals
Other effects: organ weight change
Rat, oral, 2 years:
NOEL tumour: 2.91 mg/kg body weight/day
NOAEL toxicity: 0.58 mg/kg body weight/day
Tumours: bone marrow (sarcoma)
Target organs/systems : eyes
Tumours not related to treatment.
Mouse, oral, 2 years:
NOEL tumour: > 37.8 mg/kg body weight/day
NOAEL toxicity: 3.56 mg/kg body weight/day
Tumours: none
Target organs/systems : kidneys
Other effects: decrease of body weight gain, organ weight change
Toxicity to reproduction/fertility
Rat, oral, 2 generations:
NOEL toxicity: 0.8 mg/kg body weight/day
NOEL reproduction: 4 mg/kg body weight/day
Target organs/systems in parents: eyes
Other effects in parents: decrease of body weight gain, decrease of food consumption