MSDS

Monsanto Company, Lawn & Garden Products Page: 5
Roundup® Weed & Grass Killer Concentrate Plus Version: 1.4 Effective date: 06/05/2002
FIFRA category IV.
Skin irritation
Rabbit, 3 animals, OECD 404 test:
Days to heal: 2
Primary Irritation Index (PII): 0.4/8.0
Essentially non irritating.
FIFRA category IV.
Eye irritation
Rabbit, 3 animals, OECD 405 test:
Days to heal: 3
FIFRA category III.
Moderate irritation.
Acute inhalation toxicity
Rat, LC50, 4 hours, aerosol:
Practically non-toxic.
FIFRA category IV.
No 4-hr LC50 at the maximum tested concentration.
Skin sensitization
Guinea pig, Buehler test:
Positive incidence: 0 %
Negative.
N-(phosphonomethyl)glycine; {glyphosate}
Mutagenicity
In vitro and in vivo mutagenicity test(s):
Not mutagenic.
Repeated dose toxicity
Rabbit, dermal, 21 days:
NOAEL toxicity: > 5,000 mg/kg body weight/day
Target organs/systems : none
Other effects: none
Rat, oral, 3 months:
NOAEL toxicity: > 20,000 mg/kg diet
Target organs/systems : none
Other effects: none
Carcinogenicity
Mouse, oral, 24 months:
NOEL tumour: > 30,000 mg/kg diet
NOAEL toxicity: ~ 5,000 mg/kg diet
Tumours: none
Target organs/systems : liver
Other effects: decrease of body weight gain, histopathologic effects
Rat, oral, 24 months:
NOEL tumour: > 20,000 mg/kg diet
NOAEL toxicity: ~ 8,000 mg/kg diet
Tumours: none
Target organs/systems : eyes
Other effects: decrease of body weight gain, histopathologic effects
Toxicity to reproduction/fertility
Rat, oral, 3 generations:
NOAEL toxicity: > 30 mg/kg body weight
NOAEL reproduction: > 30 mg/kg body weight
Target organs/systems in parents: none
Other effects in parents: none
Target organs/systems in pups: none
Other effects in pups: none