MSDS

Monsanto Company, Lawn & Garden Products
Page: 7 / 10
Roundup Weed & Grass Killer Concentrate Plus Version: 1.0 Effective date: 12/15/2010
Mutagenicity
In vitro and in vivo mutagenicity test(s):
Equivocal response.
Repeated dose toxicity
Rat, inhalation, 3 weeks:
NOEL toxicity: 0.1 mg/m3
Target organs/systems: lung
Other effects: organ weight change, histopathologic effects, local irritation
Chronic effects/carcinogenicity
Dog, oral, 52 weeks:
NOAEL toxicity: 0.5 mg/kg body weight/day
Target organs/systems: eyes, adrenals
Other effects: organ weight change
Rat, oral, 2 years:
NOAEL toxicity: 0.58 mg/kg body weight/day
Target organs/systems: eyes
NOEL tumour: 2.91 mg/kg body weight/day
Tumours: bone marrow, (sarcoma)
Tumours not related to treatment.
Mouse, oral, 2 years:
NOAEL toxicity: 3.56 mg/kg body weight/day
Target organs/systems: kidneys
Other effects: decrease of body weight gain, organ weight change
NOEL tumour: > 37.8 mg/kg body weight/day
Tumours: none
Toxicity to reproduction/fertility
Rat, oral, 2 generations:
NOEL toxicity: 0.8 mg/kg body weight/day
NOEL reproduction: 4 mg/kg body weight/day
Target organs/systems in parents: eyes
Other effects in parents: decrease of body weight gain, decrease of food consumption
Other effects in pups: decrease of body weight gain, decrease of litter survival
Effects on offspring only observed with maternal toxicity.
Developmental toxicity/teratogenicity
Rat, oral, 7 - 16 days of gestation:
NOEL toxicity: < 4 mg/kg body weight/day
NOEL development: 12 mg/kg body weight/day
Other effects in mother animal: decrease of body weight gain, decrease of food consumption
Developmental effects: weight loss, skeletal variations, visceral malformations, delayed ossification
Effects on offspring only observed with maternal toxicity.
Rabbit, oral, 7 - 19 days of gestation:
NOEL toxicity: 1 mg/kg body weight/day
NOEL development: 3 mg/kg body weight/day
Other effects in mother animal: decrease of body weight gain, decrease of food consumption
Developmental effects: visceral variations, delayed ossification
Effects on offspring only observed with maternal toxicity.
Mouse, oral, 6 - 15 days of gestation:
NOEL toxicity: 1 mg/kg body weight/day
NOEL development: 2 mg/kg body weight/day
Other effects in mother animal: decrease of body weight gain, breathing irregularities, neurotoxic signs, decrease
of survival
Developmental effects: weight loss, skeletal variations
Effects on offspring only observed with maternal toxicity.
Acute neurotoxicity
Rat, oral, single dose, gavage:
NOEL: 25 mg/kg body weight
Other effects: neuromuscular effects