User Manual

Table Of Contents
14
Introduction
CoaguChek INRange User’s Manual
Test principle
The CoaguChek XS PT test strip contains a ly-
ophilized reagent (reagent in dried form). The
reactive components of this reagent consist
of thromboplastin and a peptide substrate.
When a sample is applied, thromboplastin
activates coagulation, which leads to the
formation of thrombin. At the same time the
meter starts to measure the time. The enzyme
thrombin cleaves the peptide substrate, gen-
erating an electrochemical signal. Depending
on the time elapsed when it rst appears, this
signal is then converted by means of an algo-
rithm into customary coagulation units (INR,
%Quick, seconds) and the result is displayed.
DRAFT - CONFIDENTIAL