MSDS

5
LCLo (inhalation, mouse) = 120,000
mg/kg
LD50 (rat, oral): 28,710 mg/kg
ACUTE INHALATION (mouse): 30,000 ppm, narcosis within 30 to 60 minutes; 35,000-40,000 ppm,
convulsions and death.
DERMAL (rabbit): 2 to 5 ml/kg for 4 hours resulted in restlessness and discoordination,; death
occurred at 5 ml/kg.
CHRONIC INHALATION (rat): 400-600 ppm, 5 days/week, peripheral neuropathy in 45 days; 850 ppm for
143 days, loss of weight and degeneration of the sciatic nerve.
(mouse): 250 ppm, peripheral neuropathy within 7 months; no effects at 100 ppm.
SUSPECTED CANCER AGENT: None of the Hexane isomers are found on the following lists: FEDERAL
OSHA Z LIST, NTP, IARC, or CAL/OSHA, and are therefore neither considered to be nor suspected to
be cancer-causing agents by these agencies.
IRRITANCY OF PRODUCT: The liquid or vapors of Hexane and its isomers can be irritating to
contaminated tissue.
SENSITIZATION OF PRODUCT: None of the Hexane isomers are sensitizers.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of
Hexane and its isomers on the human reproductive system.
Mutagenicity: Hexane and its isomers are not expected to cause mutagenic effects in humans. Animal
mutation data is available for n-Hexane obtained during clinical studies on specific animal tissues
exposed to high doses of this compound.
Embryotoxicity: Hexane and its isomers are not expected to cause embryotoxic effects in humans.
Teratogenicity: Hexane and its isomers are not expected to cause teratogenic effects in humans.
Studies on test animals exposed to relatively high doses of n-Hexane indicate teratogenic effects.
Reproductive Toxicity: Hexane and its isomers are not expected to cause adverse reproductive effects
in humans. Clinical studies on test animals exposed to relatively high doses of n-Hexane indicate
adverse reproductive effects.
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the
changes will propagate through generational lines. An embryotoxin is a chemical which causes
damage to a developing embryo (i.e. within the first eight weeks of pregnancy in humans), but the
damage does not propagate across generational lines. A teratogen is a chemical which causes damage
to a developing fetus, but the damage does not propagate across generational lines. A reproductive
toxin is any substance which interferes in any way with the reproductive process.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Acute or chronic respiratory conditions,
central nervous system conditions, eye disorders, or skin problems may be aggravated by
overexposure to Hexane and its isomers.
RECOMMENDATIONS TO PHYSICIANS: Treat symptoms and eliminate exposure.
BIOLOGICAL EXPOSURE INDICES: Biological Exposure Indices (BEIs) associated with Hexane
isomers are as follows:
BIOLOGICAL EXPOSURE INDICES (BEIs) for Hexane are as follows:
CHEMICAL n-HEXANE
DETERMINANT
• 2,5-Hexanedione in urine
• n-Hexane in end-exhaled air
SAMPLING TIME
• End of shift
BEI
• 5 mg/g creatinine
• Refer to current TLV list.
SECTION 12 - ECOLOGICAL INFORMATION
No specific information available.