SDS

Guardian Chlorinating Granules (47%) Page 7
significantly greater than the concentrations used for disinfection. Based on high cellular toxicity in in
vitro assays and the lack of mutagenicity in animals, the risk of genetic damage to humans is judged
not significant.
Calcium Chloride: This product was determined to be non-mutagenic in the Ames assay. It was also
shown to be non-clastogenic in the chromosomal aberration test.
Carcinogenicity: This product is not know or reported to be carcinogenic by any reference source
including IARC, OSHA, NTP or EPA. One hundred mice were exposed dermally 3 times a week for
18 months to a solution of calcium hypochlorite. Histopathological examination failed to show an
increased incidence of tumors. IARC (Internal Agency for Research on Cancer) reviewed studies
conducted with several hypochlorite salts. IARC has classified hypochlorite salts as having
inadequate evidence for carcinogenicity to humans and animals. IARC therefore considers
hypochlorite salts to be not classifiable as to their carcinogenicity to humans (Group 3 Substance).
Calcium Chloride: This chemical is not known or reported to be carcinogenic by any reference source
including IARC, OSHA, NTP, or EPA.
12. ECOLOGICAL INFORMATION
Overview: Highly toxic to fish and other aquatic organisms.
Ecological Toxicity Values – Product:
Bluegill: (Nominal static). 96 h LC50 Approximately 0.12 mg/l. Based on extrapolation from studies
using calcium hypochlorite.
Rainbow Trout (Salmo gairdneri): (Nominal static) 96 h LC50. Approximately 0.22 mg/l, Based on
extrapolation from studies using calcium hypochlorite.
Daphnia magna: (Nominal static). 48 h LC50. Approximately 0.15 mg/l. Based on extrapolation from
studies using calcium hypochlorite.
Bobwhite quail: LC50 > 7,000 ppm. Based on extrapolation from studies using calcium hypochlorite.
Mallard ducklings: LC50 > 7,000 ppm. Based on extrapolation from studies using calcium
hypochlorite.
Bobwhite quail: LD50 approximately 4,800 mg/kg. Based on extrapolation from studies using calcium
hypochlorite.
Ecological Toxicity Values for Calcium Hypochlorite:
Bluegill: (Nominal static). 96 h LC50 0.088 mg/l
Rainbow Trout (Salmo Gairdner): (Nominal static). 96 h LC50 0.16 mg/l
Daphnia magna: (Nominal static), 48 h LC50, 0.11 mg/l
Bobwhite quail: Dietary LC50 > 5,000 ppm
Mallard Ducklings: Dietary LC50 > 5,000 ppm
Bobwhite quail: Oral LD50 3,474 mg/kg
Ecological Toxicity Values for Calcium Chloride
Bluegill: (Nominal static), 96 h LC50 = 10.650 mg/l
Mosquito Fish: (Nominal static). 96 h LC50 = 13,400 mg/l
Fathead minnow (Pimephales promelas): (Nominal static). 96 h LC50 = 4,630 mg/l
Daphnia magna: (Nominal static). 48 h LC50 = 2,770 mg/l
Ceriodaphnia dubia: (Nominal static). 48 h LC50 = 1,830 mg/l
Nitzschia linearis (diatom): (Nominal static). 5 day LC50 = 3,130 mg/l
13. DISPOSAL CONSIDERATIONS
Care must be taken to prevent environmental contamination from the use of the material. The user of
the material has the responsibility to dispose of unused material, residues and containers in