SDS

SDS 484
PRESTONE ® DexCool 50/50 Prediluted
Extended Life ANTIFREEZE/COOLANT
Date Prepared: 05/01/19
Page 6 of 8
teratogenicity (2,500 mg/m3). The no-effects concentration (based on maternal toxicity) was 500 mg/m3. In a further study in
mice, no teratogenic effects could be produced when ethylene glycol was applied to the skin of pregnant mice over the period of
organogenesis. The above observations suggest that ethylene glycol is to be regarded as an animal teratogen; there is currently
no available information to suggest that ethylene glycol caused birth defects in humans. Cutaneous application of ethylene
glycol is ineffective in producing developmental toxicity; exposure to high aerosol concentration is only minimally effective in
producing developmental toxicity; the major route for producing developmental toxicity is perorally.
Two chronic feeding studies, using rats and mice, have not produced any evidence that ethylene glycol causes dose-related
increases in tumor incidence or a different pattern of tumors compared with untreated controls. The absence of carcinogenic
potential for ethylene glycol has been supported by numerous invitro genotoxicity studies showing that it does not produce
mutagenic or clastogenic effects.
In a study of Wistar rats, adverse developmental results were reported at a dose of 100 mg / kg of body weight for 2-Ethyl
Hexanoic Acid, Sodium Salt.
This product contains less than 0.2% tolytriazole which has demonstrated mutagenic activity in a bacterial test system. A
correlation has been established between mutagenic activity and carcinogenic activity for many chemicals. Tolytriazole has not
been identified as a carcinogen or probable carcinogen by NTP, IARC, ACGIH, or OSHA.
12. Ecological Information
ECOTOXICITY:
Ethylene Glycol: LC50 Fathead Minnow <10,000 mg/L/96 hr.
EC50 Daphnia Magna 100,000 mg/L/48 hr
Bacterial (Pseudomonas putida): 10,000 mg/l
Protozoa (Entosiphon sulcatum and Uronema parduczi; Chatton-Lwoff): >10,000 mg/l
Algae (Microcystis aeruginosa): 2,000 mg/l
Green algae (Scenedesmus quandricauda): >10,000 mg/l
Diethylene Glycol: LC50 western mosquitofish >32,000 mg/L/96 hr
PERSISTENCE AND DEGRADABILITY:
Ethylene Glycol is readily biodegradable (97-100% in 2-12 days). Diethylene glycol is readily biodegradable (>70%
in 19 days).
BIOACCUMULATIVE POTENTIAL:
Ethylene glycol: A BCF of 10, reported for ethylene glycol in fish, Golden ide (Leuciscus idus melanotus), after 3 days
of exposure suggests the potential for bio concentration in aquatic organisms is low.
Diethylene glycol: An estimated BCF of 3 suggests the potential for bio concentration in aquatic organisms is low.
MOBILITY IN SOIL: Ethylene glycol and diethylene glycol are highly mobile in soil.
OTHER ADVERSE EFFECTS: None known
13. Disposal Considerations
Dispose of product in accordance with all local, state/provincial and federal regulations.
14. Transport Information
U.S. DOT HAZARD CLASSIFICATION: Not regulated (unless package contains a reportable quantity)
Note: IF A SHIPMENT OF A REPORTABLE QUANTITY (9,090 LBS/933 GAL.) IN A SINGLE PACKAGE IS
INVOLVED, THE FOLLOWING INFORMATION APPLIES:
PROPER SHIPPING NAME: RQ, Environmentally hazardous substance, liquid, n.o.s. (Ethylene glycol)