SDS

SAMSUNG SDI Co., Ltd.
Date: January 1
st
2019 Revision no.: 01
MODEL INR18650-25R
Page 17 of 24
Micronucleus Test(OECD TG 474, GLP)
- Carbon black : Negative reactions were observed in both in vitro(Bacterial gene mutation test(OECD
TG 471, GLP), Chromosomal aberrations test(OECD TG 476)) and in vivo(DNA damage and/or repair
test).
- 1-Methyl-2-pyrrolidinone : Negative reactions were observed in both in vitro (Chromosomal
aberrations test (OECD Guideline 476, GLP)) and in vivo (Mammalian Erythrocyte Micronucleus Test
(OECD Guideline 474, GLP)).
- Chromium : In vitro mammalian chromosome aberration test, the result of the assay was negative.
(Read across; stainless steel)(OECD TG 473, GLP)
- Lithium carbonate;Lithane : Negative reactions were observed in vitro (Bacterial Reverse Mutation
Assay(OECD Guideline 471, GLP)).
- Ethylbenzene : Negative reactions were observed in in vitro-mammalian chromosome aberration
test(OECD TG 473), mammalian cell gene mutation test (OECD TG 476, GLP) and in vivo-
unscheduled DNA synthesis (UDS) test with mammalian liver cells (OECD TG 486, GLP), mammalian
erythrocyte micronucleus test (OECD TG 474, GLP).
Reproductive toxicity :
- Graphite :
- Copper : In reproductive toxicity with rats, there were no effects considered (up to 1500 ppm).
(OECD TG 416, GLP)
- Aluminum : No reproduction, breeding and early post-natal developmental toxicity was observed in
rats at 1000 mg/kg bw for males and females. (OECD TG 422, GLP)(Aluminium chloride; read across)
- Lithium hexafluorophosphate(1-) : In the two-generation reproductive toxicity with rats, no effects
observed on reproductive toxicity. (male/female)(OECD Guideline 416, GLP)(OECD Guideline
414)(Information on major hydrolysis product of the registered substance (released rapidly on contact
with water/moisture))
- Boehmite (Al(OH)O) : No reproduction, breeding and early post-natal developmental toxicity was
observed in rats at 1000 mg/kg body weight for males and females.(OECD Guideline 422, GLP)
- Carbon black : No adverse effects on the reproductive function are expected.(OECD TG 414)
- Chromium : In the 90 days inhalation toxicity study using rat, there were no effects on clinical signs,
mortality.(OECD TG 413)
- Ethylbenzene : There were no adverse effects on reproductive or developmental endpoints at dose
levels up to 500 ppm EB in this guideline two-generation rat inhalation study. OECD TG 416, GLP);
Results of prenatal Developmental Toxicity tests for rats, litter size was comparable between the
treated and control dose groups, while a statistically significant dose-related reduction in fetal weights
were noted in the 1000 and 2000 ppm dose groups. Visceral malformations occurred in one or few
fetuses from the 100, 1000 and 2000 ppm exposure groups, without a clear dose relationship and no
statistical significance. NOAEC = 2000ppm (OECD Guideline 414)
Specific target organ toxicity (single exposure) :
- Fe : If inhaled, iron is a local irritant to the lung and gastrointestinal tract.
- Copper : All animals showed expected gains in bodyweight over the study period and there were no
abnormalities noted at necropsy. (OECD TG 423, GLP)
- Aluminum : In test using rats, Clinical signs of depression, laboured respiration, piloerection and
hunched appearance was noted at the highest dose 15900 mg/kg. Macroscopic examination at the
end of the observation period did not reveal any aluminium-related changes of the internal organs of
the aluminium treated animals compared to the control group. (OECD TG 401)(Fumed alumina; read
across)
- Lithium hexafluorophosphate(1-) : Clinical signs observed during the study period were lethargy,
hunched posture, uncoordinated movements, piloerection at 300 mg/kg, hunched posture, piloerection
at 50 mg/kg. The surviving animals had recovered from the symptoms by Day 3.(OECD Guideline 423,
GLP)
- Polyethylene : No test substance-related toxic effects were observed in an acute oral toxicity study
with rats.