Safety data sheet

MSDS-No.: 41529
V001.0
Ponal Classic
Page 6 of 10
Acute dermal toxicity:
Hazardous components
CAS-No.
Value
type
Value
Route of
application
Exposure
time
Species
Method
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
LD50
> 5.000 mg/kg
dermal
rat
EPA OPP 81-2 (Acute Dermal
Toxicity)
Isothiazolinone mixture
3:1 (CIT/MIT)
55965-84-9
LD50
87,12 mg/kg
dermal
rabbit
OECD Guideline 402 (Acute
Dermal Toxicity)
Skin corrosion/irritation:
Hazardous components
CAS-No.
Result
Exposure
time
Species
Method
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
moderately irritating
4 h
rabbit
EPA OPP 81-5 (Acute Dermal
Irritation)
Isothiazolinone mixture
3:1 (CIT/MIT)
55965-84-9
corrosive
not specified
Serious eye damage/irritation:
Hazardous components
CAS-No.
Result
Exposure
time
Species
Method
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
highly irritating
48 h
rabbit
EPA OPP 81-4 (Acute Eye
Irritation)
Respiratory or skin sensitization:
Hazardous components
CAS-No.
Result
Test type
Species
Method
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
sensitising
Mouse
local
lymphnod
e assay
(LLNA)
guinea pig
Magnusson and Kligman
Method
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
sensitising
Mouse
local
lymphnod
e assay
(LLNA)
mouse
OECD Guideline 429 (Skin
Sensitisation: Local Lymph
Node Assay)
Isothiazolinone mixture
3:1 (CIT/MIT)
55965-84-9
Sensitizing
guinea pig
not specified
Germ cell mutagenicity:
Hazardous components
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
negative
oral: gavage
mouse
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
negative
oral: unspecified
rat
OECD Guideline 486
(Unscheduled DNA Synthesis
(UDS) Test with Mammalian
Liver Cells in vivo)