Safety data sheet

MSDS-No.: 430371
V001.1
Ponal Fix & Fest
Page 6 of 9
Respiratory or skin sensitization:
Hazardous components
CAS-No.
Result
Test type
Species
Method
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
sensitising
Guinea pig
maximisat
ion test
guinea pig
Magnusson and Kligman
Method
Germ cell mutagenicity:
Hazardous components
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
negative
mouse
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
negative
oral: unspecified
rat
OECD Guideline 486
(Unscheduled DNA Synthesis
(UDS) Test with Mammalian
Liver Cells in vivo)
negative
oral: gavage
mouse
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
Repeated dose toxicity
Hazardous components
CAS-No.
Result
Route of
application
Exposure time /
Frequency of
treatment
Species
Method
1,2-Benzisothiazol-3(2H)-
one
2634-33-5
NOAEL=10 mg/kg
oral: gavage
90 daysdaily
rat
OECD Guideline 408
(Repeated Dose 90-Day Oral
Toxicity in Rodents)
SECTION 12: Ecological information
General ecological information:
The mixture is classified based on the available hazard information for the ingredients as defined in the classification criteria for
mixtures for each hazard class or differentiation in Annex I to Regulation 1272/2008/EC. Relevant available health/ecological
information for the substances listed under Section 3 is provided in the following.
Do not empty into drains, soil or bodies of water.