SDS

Product:
REFRIGERANT GAS R-410A
Page: 5 / 8
SDS No.: CN1367(Version:1.1 ) Date 20.03.2014
DIFLUOROMETHANE :
At high vapour/fog concentrations :, headache, Dizziness, Drowsiness
As with other volatile aliphatic halogenated compounds, through vapour accumulation and/or inhalation
of large quantities, the product can cause :, Loss of consciousness and cardiac disorders aggravated by
stress and lack of oxygen, risk of mortality
• In animals : No mortality/4 h/rat: 520000 ppm (Method: OECD Test Guideline 403)
PENTAFLUOROETHANE :
Effects of breathing high concentrations of vapour may include:, headache, Dizziness, Drowsiness
As with other volatile aliphatic halogenated compounds, through vapour accumulation and/or inhalation
of large quantities, the product can cause :, Loss of consciousness and cardiac disorders aggravated by
stress and lack of oxygen, risk of mortality
• In animals : No mortality/4 h/rat: 800000 ppm (Method: OECD Test Guideline 403)
Local effects ( Corrosion / Irritation / Serious eye damage ):
Skin contact:
Ejection of liquefied gas : frostbite possible
Eye contact:
Ejection of liquefied gas : frostbite possible
Respiratory or skin sensitization:
Inhalation: No data available.
Skin contact:
Not relevant (gas)
CMR effects :
Mutagenicity: According to its composition, can be considered as : Not genotoxic
In vitro
DIFLUOROMETHANE :
Ames test in vitro: Inactive (Method: OECD Test Guideline 471)
In vitro chromosomal abnormality test on human lymphocytes: Inactive (Method: OECD Test Guideline
473)
In vitro gene mutations test on mammalian cells: Inactive (Method: OECD Test Guideline 476)
PENTAFLUOROETHANE :
Ames test: negative (Method: OECD Test Guideline 471)
In vitro test for chromosomal abnormalities on CHO cells: negative (Method: OECD Test Guideline 473)
In vitro chromosomal abnormality test on human lymphocytes: negative (Method: OECD Test Guideline
476)
In vivo
DIFLUOROMETHANE :
Micronucleus test in vivo mouse: Inactive (Method: OECD Test Guideline 474)
PENTAFLUOROETHANE :
Micronucleus test in vivo mouse: negative (Method: OECD Test Guideline 474)
Carcinogenicity: Based on the available data, the substance is not suspected of having carcinogenic potential
Reproductive toxicity:
Fertility: Based on the available data, the substance is not suspected of having reprotoxic potential.
DIFLUOROMETHANE :
• In animals :
NOAEL: > 50 000 ppm (rat, mouse, Inhalation)
Foetal development:
DIFLUOROMETHANE :
• In animals :
NOAEL: > 50 000 ppm Maternal concentration without effect: > 50 000 ppm (Method: OECD Test
Guideline 414, rat, rabbit, By inhalation)
PENTAFLUOROETHANE :
• In animals :
NOAEL: 245 mg/l (Method: OECD Test Guideline 414)
Maternal concentration without effect: 245 mg/l
(Method: OECD Test Guideline 414, rat, rabbit, By inhalation)