SDS

PERGO SDS EFFECTIVE DATE: MARCH 3, 2015
PAGE 6 OF 9
11. TOXICOLOGICAL INFORMATION (Continued)
TOXICITY DATA (continued):
PROPYLENE GLYCOL (continued):
LDLo (Intravenous-Rabbit) 4200 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax, or
Respiration: respiratory depression
LDLo (Intramuscular-Mouse) 6300 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax, or
Respiration: respiratory depression
TDLo (Oral-Rat) 88,269 mg/kg/30 days-intermittent: Endocrine: hyperglycemia
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels:
phosphatases, transaminases
TDLo (Oral-Rat) 84 mL/kg/30 days-continuous: Blood: changes in serum composition
(e.g. TP, bilirubin, cholesterol) Blood: changes in leukocyte (WBC) count;
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels:
multiple enzyme effects
TDLo (Oral-Dog) 3650 mg/kg/2 years-intermittent: Blood: normocytic anemia, other
hemolysis with or without anemia
TDLo (Skin-Mouse) 1,284,800 mg/kg/2 years-intermittent: Skin and Appendages:
tumors
TDLo (Intraperitoneal-Rat) 19,500 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax, or
Respiration: respiratory depression
TDLo (Intraperitoneal-Mouse) 100 mg/kg: female 11 day(s) after conception:
Reproductive: Fertility: post-implantation mortality (e.g. dead and/or resorbed
implants per total number of implants)
TDLo (Intraperitoneal-Mouse) 100 mg/kg: female 15 day(s) after conception:
Reproductive: Effects on Embryo or Fetus: fetotoxicity (except death, e.g., stunted
fetus)
TCLo (Inhalation-Rat) 2180 mg/m
3
/6 hours/90 days-intermittent: Behavioral: food intake
(animal); Endocrine: changes in spleen weight; Biochemical: Enzyme inhibition,
induction, or change in blood or tissue levels: dehydrogenases
PROPYLENE GLYCOL (continued):
DNA Inhibition (Subcutaneous-Mouse) 8000 mg/kg
Cytogenetic Analysis (Subcutaneous-Mouse) 8000 mg/kg
Cytogenetic Analysis (Hamster Fibroblast) 32 gm/L
TITANIUM DIOXIDE:
Standard Draize Test (Skin-Human) 300 µg/3 days-intermittent: Mild
TC (Inhalation-Rat) 10 mg/m
3
/18 hours/2 years-intermittent: Tumorigenic: carcinogenic
by RTECS criteria; Lungs, Thorax, or Respiration: tumors
TCLo (Inhalation-Rat) 250 mg/m
3
/6 hours/2 years-intermittent: Tumorigenic:
carcinogenic by RTECS criteria; Lungs, Thorax, or Respiration: tumors
TD (Intramuscular-Rat) 260 mg/kg/84 weeks-intermittent: Tumorigenic: equivocal
tumorigenic agent by RTECS criteria; Blood: lymphoma, including Hodgkin's disease;
Tumorigenic: tumors at site of application
TDLo (Intratracheal-Mouse) 100 mg/kg: Tumorigenic: increased incidence of tumors in
susceptible strains
TDLo (Intramuscular-Rat) 360 mg/kg/2 years-intermittent: Tumorigenic: neoplastic by
RTECS criteria; Blood: lymphoma, including Hodgkin's disease; Tumorigenic: tumors
at site of application
DNA Damage (Human Lung) 100 µg/plate
DNA Damage (Human Lung) 20 µg/disk/4 hours
Sister Chromatid Exchange (Human Lymphocyte) 2 µmol/L/72 hours
Micronucleus Test (Human Lymphocyte) 5 µmol/L/72 hours
Micronucleus Test (Intraperitoneal-Mouse) 3 gm/kg/3 days-continuous
Micronucleus Test (Hamster Ovary) 5 µmol/L
DNA Inhibition (Hamster Lung) 500 mg/L
Sister Chromatid Exchange (Hamster Ovary) 1 µmol/L
IRRITANCY OF PRODUCT: Inhalation of fumes if product if heated or if applied in confined space may cause respiratory
irritation. Eye contact may cause irritation. Prolonged skin contact may cause irritation.
SENSITIZATION OF PRODUCT: This product contains trace amounts of Formaldehyde, which is known to cause skin
sensitization. Persons susceptible or already sensitized to Formaldehyde may experience an allergic reaction.
CARCINOGENIC POTENTIAL OF COMPONENTS: Components of this product are listed by agencies tracking the
carcinogenic potential of chemical compounds, as follows:
MINERAL SPIRITS: IARC-3 (Unclassifiable as to Carcinogenicity in Humans)
QUARTZ SILICA: ACGIH-TLV-A2 (Suspected Human Carcinogen); IARC-1 (Carcinogenic to Humans); MAK-1 (Substances that Cause Cancer in Man and Can Be Assumed
to Make a Significant Contribution to Cancer Risk); NIOSH-Ca (Potential Occupational Carcinogen with No Further Categorization); NTP-K (Known to Be a Human
Carcinogen)
TITANIUM DIOXIDE: ACGIH TLV-A3 (Confirmed Animal Carcinogen); IARC-3 (Unclassifiable as to Carcinogenicity in Humans); NIOSH-Ca (Potential Occupational
Carcinogen, with No Further Categorization)
The remaining components are not found on the following lists: U.S. EPA, U.S. NTP, U.S. OSHA, U.S. NIOSH,
GERMAN MAK, IARC, or ACGIH and therefore is neither considered to be nor suspected to be a cancer-causing
agent by these agencies.
REPRODUCTIVE TOXICITY INFORMATION: Components of this product have no reported mutagenic, embryotoxic,
teratogenic or reproductive toxicity.
ACGIH BIOLOGICAL EXPOSURE INDICES (BEIs): Currently, there are no ACGIH Biological Exposure Indices (BEIs)
determined for this material.
12. ECOLOGICAL INFORMATION
ALL WORK PRACTICES MUST BE AIMED AT ELIMINATING ENVIRONMENTAL CONTAMINATION.
MOBILITY: This product has not been tested for mobility in soil.
PERSISTENCE AND BIODEGRADABILITY: This product has not been tested for persistence or biodegradability.
BIO-ACCUMULATION POTENTIAL: This product has not been tested for bio-accumulation potential.
ECOTOXICITY: This product has not been tested for aquatic or animal toxicity. All releases to terrestrial, atmospheric and
aquatic environments should be avoided. No aquatic toxicity data are available for the product or components in 1%
concentration or more.
OTHER ADVERSE EFFECTS: This material is not listed as having ozone depletion potential.
ENVIRONMENTAL EXPOSURE CONTROLS: Controls should be engineered to prevent release to the environment,
including procedures to prevent spills, atmospheric release and release to waterways.
13. DISPOSAL CONSIDERATIONS
DISPOSAL METHODS: It is the responsibility of the generator to determine at the time of disposal whether the product
meets the criteria of a hazardous waste per regulations of the area in which the waste is generated and/or disposed of.
Waste disposal must be in accordance with appropriate Federal, State, and local regulations. This product, if unaltered
by use, may be disposed of by treatment at a permitted facility or as advised by your local hazardous waste regulatory
authority. Shipment of wastes must be done with appropriately permitted and registered transporters.
DISPOSAL CONTAINERS: Waste materials must be placed in and shipped in appropriate 5-gallon or 55-gallon poly or
metal waste pails or drums. Permeable cardboard containers are not appropriate and should not be used. Ensure that
any required marking or labeling of the containers be done to all applicable regulations.
PRECAUTIONS TO BE FOLLOWED DURING WASTE HANDLING: Wear proper protective equipment when handling
waste materials.
U.S. EPA WASTE NUMBER: Not applicable.