SDS
PERGO SDS EFFECTIVE DATE: MARCH 3, 2015
PAGE 5 OF 9
11. TOXICOLOGICAL INFORMATION (Continued)
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in
Lay Terms. Exposure to this product may cause the following health
effects:
Acute: Inhalation of fumes or vapors may cause irritation of respiratory system.
Eye contact may cause irritation.
Chronic: Prolonged or repeated skin exposure may cause dermatitis (dry red skin).
TARGET ORGANS: Acute: Skin, eyes, respiratory system. Chronic: Skin.
TOXICITY DATA: Currently, the following toxicological data are available for
some components of 1% or more concentration.
ACRYLIC POLYMERS:
LD
50
(Oral-Rat) > 5000 mg/kg
LD
50
(Skin-Rabbit) > 5000 mg/kg
CALCIUM CARBONATE:
TDLo (Intravenous-Rat) 30 mg/kg: Vascular: BP lowering not characterized in
autonomic section; Lungs, Thorax, or Respiration: changes in lung weight; Blood:
other changes
TCLo (Inhalation-Rat) 84 mg/m
3
/4 hours/40 weeks-intermittent: Lungs, Thorax, or
Respiration: fibrosis (interstitial); Liver: other changes; Kidney/Ureter/Bladder: other
changes
TCLo (Inhalation-Rat) 250 mg/m
3
/2 hours/24 weeks-intermittent: Lungs, Thorax, or
Respiration: fibrosis, focal (pneumoconiosis)
MINERAL SPIRITS:
TCLo (Inhalation-Rat) 275 mg/m
3
/6 hours/16 days-intermittent: Liver: changes in liver
weight
TCLo (Inhalation-Rat) 2200 mg/m
3
/6 hours/16 days-intermittent: Liver: other changes
TCLo (Inhalation-Rat) 275 mg/m
3
/6 hours/16 days-intermittent: Nutritional and Gross
Metabolic: weight loss or decreased weight gain
TCLo (Inhalation-Rat) 138 mg/m
3
/6 hours/16 days-intermittent: Liver: changes in liver
weight; Kidney/Ureter/Bladder: changes in kidney weight; Related to Chronic Data:
changes in testicular weight
TCLo (Inhalation-Rat) 550 mg/m
3
/6 hours/16 days-intermittent: Kidney/Ureter/Bladder:
other changes in urine composition, changes in kidney weight; Reproductive:
Paternal Effects: spermatogenesis (incl. genetic material, sperm morphology,
motility, and count)
TCLo (Inhalation-Rat) 2200 mg/m
3
/6 hours/16 days-intermittent: Sense Organs and
Special Senses (Olfaction): effect, not otherwise specified
TCLo (Inhalation-Rat) 2200 mg/m
3
/6 hours/16 days-intermittent: Related to Chronic
Data: death
TCLo (Inhalation-Rat) 550 mg/m
3
/6 hours/16 days-intermittent: Kidney/Ureter/Bladder:
other changes
TCLo (Inhalation-Rat) 550 mg/m
3
/6 hours/16 days-intermittent: Endocrine: thyroid
tumors
TCLo (Inhalation-Rat) 1100 mg/m
3
/6 hours/16 days-intermittent: Kidney/Ureter/Bladder:
other changes, Kidney tumors
TCLo (Inhalation-Rat) 138 mg/m3/91 days-intermittent: Liver: changes in liver weight;
Kidney/Ureter/Bladder: changes in kidney weight; Related to Chronic Data: changes
in testicular weight
TCLo (Inhalation-Rat) 1100 mg/m3/91 days-intermittent: Liver: changes in liver weight;
Kidney/Ureter/Bladder: changes in kidney weight
TCLo (Inhalation-Rat) 550 mg/m3/91 days-intermittent: Kidney/Ureter/Bladder: changes
in tubules (including acute renal failure, acute tubular necrosis), other changes
TCLo (Inhalation-Rat) 550 mg/m3/2 years-intermittent: Endocrine: other changes,
tumors
TCLo (Inhalation-Rat) 2200 mg/m3/91 days-intermittent: Kidney/Ureter/Bladder: other
changes
TCLo (Inhalation-Mouse) 275 mg/m
3
/6 hours/16 days-intermittent: Liver: changes in
liver weight
TCLo (Inhalation-Mouse) 2200 mg/m
3
/6 hours/16 days-intermittent: Liver: other
changes
TCLo (Inhalation-Mouse) 2200 mg/m
3
/6 hours/16 days-intermittent: Liver: changes in
liver weight; Reproductive: Paternal Effects: spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
TCLo (Inhalation-Mouse) 138 mg/m
3
/6 hours/16 days-intermittent: Blood: changes in
spleen
TCLo (Inhalation-Mouse) 550 mg/m
3
/6 hours/16 days-intermittent: Nutritional and Gross
Metabolic: weight loss or decreased weight gain
TCLo (Inhalation-Mouse) 2200 mg/m
3
/6 hours/16 days-intermittent: Liver: tumors
TCLo (Inhalation-Mouse) 1100 mg/m
3
/91 days-intermittent: Liver: changes in liver
weight
TCLo (Inhalation-Mouse) 2200 mg/m
3
/91 days-intermittent: Reproductive: Paternal
Effects: spermatogenesis (incl. genetic material, sperm morphology, motility, and
count)
TCLo (Inhalation-Mouse) 2200 mg/m
3
/2 years-intermittent: Liver: other changes, tumors
TCLo (Inhalation-Mouse) 1100 mg/m
3
/2 years-intermittent: Liver: other changes
PROPYLENE GLYCOL:
Standard Draize Test (Skin-Human) 500 mg/7 days: Mild
Standard Draize Test (Skin-Human) 104 mg/3 days-intermittent: Moderate
Standard Draize Test (Skin-Man) 10%/2 days
Standard Draize Test (Skin-Child) 30%/96 hours-continuous: Moderate
Open Irritation Test (Skin-woman) 30%/96 hours: Mild
TDLo (Oral-Child) 79 gm/kg/56 weeks-intermittent: Brain and Coverings: changes in
surface EEG; Behavioral: general anesthetic, convulsions or effect on seizure
threshold
TDLo (Skin-Human) 10 pph: Skin and Appendages: dermatitis, allergic (after topical
exposure)
TDLo (Parenteral-Infant) 10 gm/kg/3 days-continuous: Nutritional and Gross Metabolic:
other changes
TDLo (Skin-Human) 5 mg/kg/7 days-intermittent: Skin and Appendages: primary
irritation (after topical exposure)
TDLo (Skin-Human) 4.5 mg/kg/3 days-intermittent: Skin and Appendages: primary
irritation (after topical exposure)
PROPYLENE GLYCOL (continued):
TDLo (Skin-Human) 10 pph/48 hours-continuous: Skin and Appendages: dermatitis,
allergic (after topical exposure)
TDLo (Skin-Man) 0.03 mL/kg/22 days-intermittent: Skin and Appendages: cutaneous
sensitization, experimental (after topical exposure)
TDLo (Intravenous-Woman) 5167 mg/kg/13 days-continuous: Nutritional and Gross
Metabolic: metabolic acidosis
Standard Draize Test (Eye-Rabbit) 100 mg: Mild
Standard Draize Test (Eye-Rabbit) 500 mg/24 hours: Mild
LD
50
(Oral-Rat) 20 gm/kg
LD
50
(Oral-Mouse) 22 gm/kg
LD
50
(Oral-Mouse) 20,300 mg/kg: Behavioral: ataxia, tetany; Lungs, Thorax, or
Respiration: respiratory depression
LD
50
(Oral-Rabbit) 18,500 mg/kg
LD
50
(Oral-Dog) 22 gm/kg
LD
50
(Oral-Dog) 22,000 mg/kg: Behavioral: ataxia, tetany; Lungs, Thorax, or
Respiration: respiratory depression
LD
50
(Oral-Guinea Pig) 18,350 mg/kg
LD
50
(Oral-Guinea Pig) 19,000 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax, or
Respiration: respiratory depression
LD
50
(Oral-Quail) > 2080 mg/kg
LD
50
(Skin-Rabbit) 20,800 mg/kg
LD
50
(Skin-Rabbit) 20,800 mg/kg: Behavioral: ataxia, tetany; Lungs, Thorax, or
Respiration: respiratory depression
LD
50
(Intraperitoneal-Rat) 6660 mg/kg
LD
50
(Intraperitoneal-Mouse) 9718 mg/kg: Lungs, Thorax, or Respiration: chronic
pulmonary edema; Kidney/Ureter/Bladder: changes in both tubules and glomeruli;
Blood: changes in spleen
LD
50
(Intraperitoneal-Mouse) 11,400 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax,
or Respiration: respiratory depression
LD
50
(Subcutaneous-Rat) 22,500 mg/kg
LD
50
(Subcutaneous-Rat) 28,000 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax, or
Respiration: respiratory depression
LD
50
(Subcutaneous-Mouse) 17,370 mg/kg: Behavioral: changes in motor activity
(specific assay), muscle contraction or spasticity; Lungs, Thorax, or Respiration:
cyanosis
LD
50
(Subcutaneous-Mouse) 17,400 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax,
or Respiration: respiratory depression
LD
50
(Intravenous-Rat) 6800 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax, or
Respiration: respiratory depression
LD
50
(Intravenous-Rat) 6423 mg/kg
LD
50
(Intravenous-Mouse) 8000 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax, or
Respiration: respiratory depression
LD
50
(Intravenous-Mouse) 6630 mg/kg
LD
50
(Intravenous-Dog) 26 gm/kg
LD
50
(Intravenous-Rabbit) 6500 mg/kg
LD
50
(Intramuscular-Rat) 14 gm/kg
LD
50
(Intramuscular-Rat) 20,000 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax, or
Respiration: respiratory depression
LDLo (Oral-Rabbit) 20,000 mg/kg: Behavioral: ataxia, tetany Lungs, Thorax, or
Respiration: respiratory depression
LDLo (Intramuscular-Rabbit) 6300 mg/kg: Behavioral: somnolence (general depressed
activity), coma; Lungs, Thorax, or Respiration: respiratory stimulation
LDLo (Subcutaneous-Guinea Pig) 15,500 mg/kg
LDLo (Subcutaneous-Guinea Pig) 15,500 mg/kg: Behavioral: ataxia, tetany Lungs,
Thorax, or Respiration: respiratory depression
LDLo (Intravenous-Chicken) 27 gm/kg: Vascular: other changes
HEALTH HAZARD
FLAMMABILITY HAZARD
PHYSICAL HAZARD
PROTECTIVE EQUIPMENT
1
*
EYES
RESPIRATORY
HANDS
BODY
(BLUE)
(RED)
For Routine Industrial Use and Handling Applications
SEE SECTION 8
HAZARDOUS MATERIAL IDENTIFICATION SYSTEM
(YELLOW)
1
0
SEE SECTION 8
Hazard Scale: 0 = Minimal 1 = Slight 2 = Moderate
3 = Serious 4 = Severe * = Chronic hazard