Certifications 2

SDS No.: 433400 V002.0
Pattex Haus & Bau Silicon - alle Farben
Page 15 of 22
Germ cell mutagenicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
Trimethoxyvinylsilane
2768-02-7
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Trimethoxyvinylsilane
2768-02-7
positive
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Trimethoxyvinylsilane
2768-02-7
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Octamethylcyclotetrasilox
ane
556-67-2
negative
bacterial gene
mutation assay
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Octamethylcyclotetrasilox
ane
556-67-2
negative
in vitro mammalian
chromosome
aberration test
with and without
equivalent or similar to OECD
Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Octamethylcyclotetrasilox
ane
556-67-2
negative
mammalian cell
gene mutation assay
with and without
equivalent or similar to OECD
Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Methanol
67-56-1
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Methanol
67-56-1
negative
in vitro mammalian
cell micronucleus
test
with and without
Chromosome Aberration Test
Methanol
67-56-1
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Decamethylcyclopentasilo
xane
541-02-6
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Decamethylcyclopentasilo
xane
541-02-6
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Decamethylcyclopentasilo
xane
541-02-6
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Trimethoxyvinylsilane
2768-02-7
negative
intraperitoneal
mouse
other guideline:
Octamethylcyclotetrasilox
ane
556-67-2
negative
inhalation
rat
equivalent or similar to OECD
Guideline 475 (Mammalian
Bone Marrow Chromosome
Aberration Test)
Octamethylcyclotetrasilox
ane
556-67-2
negative
oral: gavage
rat
equivalent or similar to OECD
Guideline 478 (Genetic
Toxicology: Rodent Dominant
Lethal Test)
Methanol
67-56-1
negative
intraperitoneal
mouse
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
Decamethylcyclopentasilo
xane
541-02-6
negative
inhalation
rat
OECD Guideline 486
(Unscheduled DNA Synthesis
(UDS) Test with Mammalian
Liver Cells in vivo)
Decamethylcyclopentasilo
xane
541-02-6
negative
inhalation: vapour
rat
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)