Safety data sheet

MSDS-No.: 433400
V001.0
Pattex Haus & Bau Silicon - alle Farben
Page 11 of 15
Germ cell mutagenicity:
Hazardous components
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
Siloxanes and Silicones,
di-Me
63148-62-9
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
not specified
Trimethoxyvinylsilane
2768-02-7
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
positive
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Trimethoxyvinylsilane
2768-02-7
negative
intraperitoneal
mouse
other guideline:
Methanol
67-56-1
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
negative
in vitro mammalian
cell micronucleus
test
with and without
Chromosome Aberration Test
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Methanol
67-56-1
negative
intraperitoneal
mouse
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
Carcinogenicity:
Hazardous components
CAS-No.
Result
Species
Sex
Exposure
timeFrequenc
y of treatment
Route of
application
Method
Methanol
67-56-1
not carcinogenic
mouse
male/female
18 m
19 h/d
inhalation:
vapour
OECD Guideline 453
(Combined Chronic
Toxicity / Carcinogenicity
Studies)