Specification

Information on toxicological effects
Symptoms
Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting.
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Chronic toxicity
Bifenthrin: Long-term exposure caused neurotoxicity (tremors and impaired gait) in the early
exposure in animal studies, but tremors disappeared with continued exposure.
Zeta-cypermethrin: Long-term exposure caused neurotoxicity (body tremors, decreased
motor activity), decreased body weight and increased liver and spleen weight.
Mutagenicity
Bifenthrin, Zeta-cypermethrin: Not genotoxic in animal studies.
Carcinogenicity
Bifenthrin: Weak treatment-related response for liver adenocarcinomas and benign bladder
tumors (lesion) in male mice. Cypermethrin caused an increase in benign lung tumors in
mice, but not in rats. EPA has classified cypermethrin as a possible human carcinogen
based on this information, but does not regulate based on its low cancer risk.
Neurological effects
Bifenthrin: Causes clinical signs of neurotoxicity (tremors, impaired gait, excessive
salivation) following acute or subchronic exposure. Tremors disappeared with continued
exposure Zeta-cypermethrin: Causes neurotoxicity (tremors and decreased motor activity)
following acute, subchronic, or chronic exposure.
Reproductive toxicity
Bifenthrin. Zeta-cypermethrin: No toxicity to reproduction in animal studies.
Developmental toxicity
Bifenthrin, Zeta-cypermethrin: Not teratogenic in animal studies.
STOT - single exposure
Not classified.
STOT - repeated exposure
Not classified.
Target organ effects
Bifenthrin: Central Nervous System (CNS), Zeta-cypermethrin: Central Nervous System,
blood.
Neurological effects
Bifenthrin: Causes clinical signs of neurotoxicity (tremors, impaired gait, excessive
salivation) following acute or subchronic exposure. Tremors disappeared with continued
exposure. Zeta-cypermethrin: Causes neurotoxicity (tremors and decreased motor activity)
following acute, subchronic, or chronic exposure.
Aspiration hazard
No information available.
Chemical name ACGIH IARC NTP OSHA
crystalline silica, quartz
14808-60-7
A2 Group 1 Known X
12. ECOLOGICAL INFORMATION
Ecotoxicity
Bifenthrin (82657-04-3)
Active Ingredient(s) Duration Species Value Units
Bifenthrin 96 h LC50 Fish 0.1 µg/L
72 h EC50 Algae 0.822 mg/L
48 h EC50 Crustacea 0.11 µg/L
21 d NOEC Fish 0.012 µg/L
21 d NOEC Crustacea 0.0013 µg/L
Zeta-cypermethrin (F2700) (52315-07-8)
Active Ingredient(s) Duration Species Value Units
Zeta-cypermethrin 48 h EC50 Crustacea 0.14 µg/L
96 h LC50 Fish 0.69 µg/L
72 h EC50 Algae >1 mg/L
21 d NOEC Crustacea 0.01 µg/L
21 d NOEC Fish 0.015 µg/L
Persistence and degradability
Bifenthrin: Moderately persistent. Does not readily hydrolyze. Not readily biodegradable.
Zeta-cypermethrin: Non-persistent. Readily hydrolyzed. Not readily biodegradable.
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