SyringePump.com yringePump.com Models: NE-500 / NE-501 Multi-Phaser™ NE-1000 Series of Programmable Syringe Pumps Infusion Rate 60 50 40 30 20 10 0 0 10 20 30 40 50 60 70 80 90 Time “WHAT’S YOUR APPLICATION?”™ WARNING NOT FOR CLINICAL USE ON HUMANS Publication #1200-03 Revision 17 V3.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Quick Start Instructions Assumes that the pump was not previous programmed with a multiple Phase Pumping Program. • • • • • Plug in the pump. Attach the computer cable to the "Computer" connection on the RJ-11 connector. Start the terminal emulator program on the computer (downloadable from the web site).
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Table of Contents 1. GENERAL INFORMATION........................................................................................... 1 1.1 1.2 1.3 1.4 2. WARNINGS ! AND CAUTIONS ! .............................................................................. 1 DISCLAIMER .................................................................................................................... 1 WARRANTY ...........................
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 7.3.6 JUMP TO PHASE ....................................................................................................... 13 7.3.7 SUB-PROGRAM SELECTION INPUT .......................................................................... 13 7.3.8 ................................................................................... SUB-PROGRAM START LABEL 7.3.9 ......................................................................
New Era Pump Systems Inc. 9.3 10. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ TTL I/O CONTROL FROM RS-232 ............................................................................... 40 APPENDIX ...................................................................................................................... 41 10.1 RS-232 COMMAND SUMMARY ................................................................................. 41 10.2 RS-232 PUMP NETWORK CONNECTOR WIRING ......................
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 1. General Information Thank you for purchasing the NE-500 / NE-501 OEM Programmable Syringe Pump. With the NE-500 / NE-501 syringe pump, you will be able to perform simple infusions or implement a complex automated dispensing system. Please familiarize yourself with the NE-500/501’s operation by reading this user's manual.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ option of New Era Pump Systems Inc., a defective unit will be either repaired or replaced.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ 2.1 Glossary of Terminology and Concepts 5 4 3 6 2 7 8 9 1 12 11 10 When a device has as many features as the NE-500/NE-501, understanding its operation could be a daunting task at first. By understanding the key concepts and terminology used in this manual, the operation of the NE-500/NE-501 will become quite intuitive.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Terminology Pumping Program: The sequence of automated operations entered into the pump. This could be as simple as a single function to pump at a single infusion rate continuously.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ ♦ Note on USB: If an RS-232 port is not available on your PC, the pump may be operated through a USB to RS-232 converter cable (available as an accessory, part #CBL-USB232). This cable attaches to the standard RS-232 to PC cable (part #CBL-PC-PUMP-7). The PC will create a virtual RS-232 communications port that communicates through the USB to RS-232 converter cable.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 5.1 Syringe Inside Diameter Set with command: DIA The syringe inside diameter can only be set while the Pumping Program is stopped. Valid syringe diameters are from 0.1 mm to 50.0 mm. If the diameter is out of this range, the response will be ‘?OOR’. Changing the syringe diameter will not zero any current settings. Section 10.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ 5.4 Pumping Rate Command: "RAT [ []]" Sets/queries the pumping rate and rate units. 5.4.1 Changing the Pumping Rate and Direction While Pumping Command: "RAT " Except with some complex Pumping Programs, the pumping rate can be changed while the pump is operating. To change the pumping rate while pumping, use the 'RAT' command to send a new rate.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ The “Volume Dispensed” accumulations, for infusion and withdrawal, are reset to 0 when: A) The pump is powered on. B) The syringe diameter is changed. C) From the RS-232 clear “Volume Dispensed” command (CLD) or Clear Dispense function. D) The accumulated Volume Dispensed rolls over from 9999 to 0. E) A sub-program is selected when the Pumping Program executes a Sub-Program Selection function. 5.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ 6.1 RS-232 Pump Network Configuration Command: ADR [ [B ] | | | ] The pump can be configured to communicate either with a computer or another pump. Communications with a computer (Address Mode) is the default setting and will be indicated by setting an address from 0 to 99. When in the default Address Mode, up to 100 pumps can be attached to a computer in a single pump network.
New Era Pump Systems Inc. www.SyringePump.com Condition Buzzer Action Alarm condition, such as pump motor stalled Steady alarm Model NE-500/NE-501 Multi-Phaser™ Any command sent to the pump will stop the alarm. 6.5 TTL I/O Operational Trigger Default Configuration Command: "TRG ", as below in Settings. Configures the default mode of the TTL I/O ‘Operational Trigger’ (pin 2) that will control the Pumping Program’s operation. This default setting can be overridden within a Pumping Program.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ The setting names are relevant to a 2 pump system, whereby the ‘Directional Control Input’ TTL pin is attached to the second pump’s ‘Pumping Direction Output’ TTL pin. In addition, “Directional Control Input” will affect how the “Sticky Direction” function operates. 6.7 Pump Motor Operating TTL Output Configuration Command: "ROM " Configures the functionality of the 'Pump Motor Operating' TTL output pin (TTL pin 7).
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 7.1 How to Enter Pumping Programs A Pumping Program can be entered directly from the pump’s keypad, or uploaded from a computer using PUMPTERM or SyringePumpPro software. A Pumping Program can be stored in a text file and edited with any word processor, which facilitates development and maintenance of the program.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Fill at the current dispense/withdraw rate: If the Fill function’s pumpng rate is set to 0.0, the previous function’s pumping rate will be used for the Fill rate. 7.3.3 Increment Rate Function Command: "FUN INC" The increment and decrement functions operate the same as the ‘RATE’ function, except that the specified rate is added (‘INC’)or subtracted (‘DEC’) from the current pumping rate.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ trigger. When a start trigger is received, the Sub-Program number is read from the Expansion Connector and the selected Sub-Program begins execution. Also, the accumulated infusion and withdrawal dispensed volumes are set to zero.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ While executing Phases within the scope of a defined loop, another ‘loop start’ and ‘loop end’ can be paired and become a defined loop within the scope of the first loop, which is referred to as the outer loop. The new loop being referred to as the inner loop. The pairing of a loop within a paired loop is referred to as nesting of loops, with each loop being one nested layer for the duration of the loops pairing.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 7.3.16 Setup Expansion Port Event Trigger Jump Phase Command: "FUN EVE " The ‘Event’ function sets a background event trap that is triggered by an external signal on a specific Expansion Port connector pin. See sec. 9, “Logic Interface: TTL Input and Output” for detailed information about the Expansion Port. This command is used in conjunction with the “FUN EVN” command.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 7.3.21.1 Trigger Event Trap Trigger Event Trap: Command: “FUN TRG 13” ‘Trigger Event Trap’ redirects a stop pump trigger to the background event trap. Instead of stopping the pump, an event defined by the ‘Event’ or ‘Event Square Wave’ function will be triggered, causing the Pumping Program to continue execution at the Phase number defined in the Event function.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ 7.4 Pumping Program Examples ml/hr Rate 7.4.1 Example 1: 2 Step Rate 500 2.5 0 30 ml Dispensed 05 Infuse 5.0 mL at 500 mL/hr, and then infuse 25.0 mL at 2.5 mL/hr. Then stop the pump. Phase 1 Function RAT Rate 500 mL/hr Volume 5.0 mL Direction Infuse Phase 2 Function RAT Rate 2.5 mL/hr Volume 25.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ When entering a function with associated data, such as with the ‘Pause’ in Phase 5 or the ‘Loop’ in Phase 6, the function is entered in 2 steps. First select the function and store it. Then enter the associated data. Phase 1 Function RAT Rate 750 mL/hr Volume 2.0 mL Direction Infuse Phase 2 Function RAT Rate 750 mL/hr Volume 0.
www.SyringePump.com New Era Pump Systems Inc. Phase 4 Function LOP 50 Phase 5 Function LPS Phase 6 Function DEC Phase 7 Function L0P 99 Phase 8 Function DEC Phase 9 Function LPS Phase 10 Function INC Phase 11 Function LOP 50 Phase 12 Function JMP 02 Rate 1.0 Volume 0.1 mL Direction Infuse Rate 1.0 Volume 0.1 mL Direction Infuse Rate 1.0 Volume 0.1 mL Direction Infuse Model NE-500/NE-501 Multi-Phaser™ Withdraw (ml/hr) Infuse 7.4.
New Era Pump Systems Inc. www.SyringePump.com Phase 5 Function LOP 02 Phase 6 Function RAT Rate 750.0 mL/hr Volume 0.5 mL Direction Infuse Phase 7 Function RAT Rate 300.0 mL/hr Volume 1.5 mL Direction Infuse Phase 8 Function BEP Phase 9 Function LPS Phase 10 Function PAS 60 Phase 11 Function RAT Rate 500.0 mL/hr Volume 3.75 mL Direction Infuse Phase 12 Function LOP 03 Phase 13 Function RAT Rate 900.0 mL/hr Volume 17.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ When the low pressure trap is triggered, the pump sets the high pressure trap (PHASE 07) and begins to increment the flow rate. The flow rate is incremented in 1.0 mL/hr steps with every 0.25 mL dispensed (PHASE 08-10). If the high pressure trap hasn’t as yet been triggered, the flow rate will max out at 25.0 mL/hr while waiting for the high pressure trap (PHASE 11).
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ The first 2 Phases set an event trap for a Syringe Filled Sensor and refills the syringe until the sensor is triggered. When the sensor triggers the event, the pump’s pusher block will be synchronized with the Pumping Program. It is assumed that the sensor is positioned to refill the syringe with 60 mL. A withdraw volume of 61 mL is set as a safety feature.
New Era Pump Systems Inc. Phase 2 Function LPS Phase 3 Function PRI Phase 4 Function PRL 01 Phase 5 Function RAT Phase 6 Function JMP 12 Phase 7 Function PRL 02 Phase 8 Function RAT Phase 9 Function JMP 12 Phase 10 Function PRL 03 Phase 11 Function RAT Phase 12 Function LOP 05 Phase 13 Function JMP 01 www.SyringePump.com Rate 100.0 mL/hr Volume 10 mL Direction Infuse Rate 500.0 mL/hr Volume 10 mL Direction Infuse Rate 750.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Output’ TTL line (PHASE 02). After 5.0 mL has been dispensed at 800 mL/hr (PHASE 03), the ‘Program Output’ TTL line is lowered (PHASE 04), sending a synchronization signal to another device. The pump then continues to pump at 800 mL/hr (PHASE 06) until a synchronization signal is received at the ‘Event Trigger’ TTL input, causing the Program to jump to Phase 7 (PHASE 05). The pump then withdraws 0.
New Era Pump Systems Inc. www.SyringePump.com Direction Infuse Model NE-500/NE-501 Multi-Phaser™ Phase 4 Function RAT Rate 500.0 mL/hr Volume 0.0 mL (OFF) Phase 5 Function FIL Rate 1000.0 mL/hr Refill syringe when foot switch is released Phase 6 Function STP Then stop the pump Then infuse continuously 8. RS-232 Communications The NE-500/NE-501 Syringe Pump can communicate with any computer, software package, or device with an RS-232 communications port. 8.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 8.3 RS-232 Protocol When the pump is used in a multi-pump network configuration, precede each command with a pump address. Pumps will ignore all commands that do not have their defined network address. If the network address is not specified in the command, the address will default to 0. After a command is sent to the pump, the pump will not accept any further communications until the current command has been processed.
New Era Pump Systems Inc. www.SyringePump.com => <> [] {} | λ "" Model NE-500/NE-501 Multi-Phaser™ Is defined by. Syntax expands to next level of expansion. Non-terminal syntax expansion Optional syntax Required syntax Or. Choose one of the syntax options. None. Syntax expands to nothing (lambda production). Description of syntax expansion 8.3.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 8.3.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Assuming that the current pumping rate units of all 3 pumps are currently mL/hr, send the following command, followed by a carriage return , (spaces are optional): 0 rat 100 * 1 rat 250 * 2 rat 375 * 8.4 Command Errors and Alarms If a command received by the pump is not recognized or the data is invalid, an error message will be in the field of the response packet following the field.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ Set: Currently selected Phase is set to . Previous Phase is stored in non-volatile memory and the requested Phase is recalled from the non-volatile memory. Set is only valid if the Pumping Program is not operating. Query response: Currently selected Phase PUMPING PROGRAM FUNCTION FUN [ ] Set/query the Pumping Program Phase’s function.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Applicable only with “Rate Data Functions”. When setting the pumping rate, if the current Phase’s function is not ‘RATE’, then is not applicable. While pumping, the pumping rate can only be set if the current Phase function is ‘RATE’ and the next Program Phase’s function to be executed is not Increment (FUN INC) or Decrement (FUN DEC). Also, while pumping, cannot be set.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 8.5.2 Pump Operational Commands START PUMPING PROGRAM RUN [ ] [E [ ] ] Starts the Pumping Program operation. If the Pumping Program was paused, then the Pumping Program resumes at the point where it was stopped. Otherwise, the Pumping Program starts from Phase 1. Sub-Programs: If a Phase number is specified (), then the Pumping Program will start at the specified Phase number.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ ALARM SETUP AL [ ] Set/query alarm setup mode. Set alarm enables or disables alarm buzzer mode. POWER FAIL SETUP PF [ ] Set/query Power Failure mode. Set Power Failure enables or disables Power Failure mode. TTL I/O OPERATIONAL TRIGGER DEFAULT SETUP TRG [ ] Set/Query TTL I/O Operational Trigger default input configuration. TTL I/O Operational Trigger is set to .
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 8.5.4 General Control and Status Commands TTL I/O OUTPUT SETTING OUT E { 1 |2 | 3 | 4 | 5 } Expansion Port Connector Sets TTL level on user definable output pin on the ‘TTL I/O’ connector. Indicates pin number on ‘TTL I/O’ connector Valid value: 5 (Program Output pin) E Sets pin on Expansion Port I/O connector on PCB. Query is not applicable.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ This is a special system command that will be accepted by the pump regardless of its current address. Once set, the pump will only respond to commands with the set address and at the specified baud rate. Note: Once a special communications mode is set, the pump will only respond to commands that are preceded by the ‘*’ character.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Note on USB: If an RS-232 port is not available on your PC, the pump may be operated through a USB to RS232 converter cable (available as an accessory, part #CBL-USB232). This cable attaches to the standard RS232 to PC cable (part #CBL-PC-PUMP-7). The PC will create a virtual RS-232 communications port that communicates through the USB to RS-232 converter cable. The terminal emulator can communicate through this virtual port.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ DB-9 Connector TTL I/O Pin # Definition Type Function 1 Vcc (5V) Reference Logic high reference. Power on indicator. 2 Operational Trigger Input Command: TRG [aa] Configurable start/stop operational trigger input.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Foot Switch Reversed: Operates like the ‘Start/Stop’ key, whereby each rising edge either starts or stops/pauses the Pumping Program. Level Control: Falling edge stops/pauses the Pumping Program, Rising edge starts the Pumping Program. This configuration can be used with a contact closure timer or in an automation setup, allowing logic level control over the operation of the pump.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 9.2 TTL I/O Control from the Pumping Program Various Pumping Program functions can define how the pump reacts to levels on the TTL I/O connector or set output levels.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 10. Appendix 10.1 RS-232 Command Summary => DIA [ < float > ] Syringe inside diameter PHN [ < phase data > ] Program Phase number FUN [ < phase function > ] Program Phase function < phase function > => RAT Pumping rate. FIL Fill syringe to volume dispensed. INC Increment rate. DEC Decrement rate. STP Stop pump. PAS Pauses pumping for ‘nn’ seconds, if 0, wait for start trigger. PAS [n.
New Era Pump Systems Inc. www.SyringePump.com *ADR [ DUAL | RECP | ALTR ] Model NE-500/NE-501 Multi-Phaser™ Set Reciprocating, Dual, or Alternating pumping mode *RESET Resets pump. Clears program memory and resets setup.
www.SyringePump.com New Era Pump Systems Inc. Model NE-500/NE-501 Multi-Phaser™ RS-232 Network Secondary Cable 7 foot cable Part #: CBL-NET-7 25 foot cable Part #: CBL-NET-25 Cable to connect additional pumps, after the first pump, to the pump network. USB to RS-232 Converter Cable USB to RS-232 cable, software drivers on CD. Part#: CBL-USB232 Attached to the RS-232 Network Primary Cable, allows communication through a PC’s USB port. 10.3.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ Pusher block makes a snap or click sound when the pump is started: This is a normal condition. When the pusher block is manually moved, the drive-nut may not have been fully engaged on the drive screw. The sound heard is the drive-nut engaging on the drive screw. Pump doesn’t stop after dispensing a set volume: The pump was previously setup with a multiple Phase Pumping Program.
New Era Pump Systems Inc. www.SyringePump.com Model NE-500/NE-501 Multi-Phaser™ 10.7 Syringe Diameters and Rate Limits Syringe Size Manufacturer (mL) (all names ™) Inside Diameter (mm) B-D 4.699 53.07 0.73 8.585 177.1 2.434 11.99 345.5 4.748 14.43 500.4 6.876 19.05 872.2 11.99 21.59 1120 15.4 26.59 1699 23.35 4.69 52.86 0.727 9.65 223.8 3.076 12.45 372.5 5.119 15.9 607.6 8.349 20.05 966.2 13.28 22.9 1260 17.32 29.2 2049 28.16 5.74 79.18 1.088 8.941 192.1 2.64 12.7 387.6 5.326 15.72 593.9 8.161 20.
