SyringePump.com Model: NE-4000 Two Channel Syringe Pump Multi-Phaser™ NE-1000 Series of Programmable Syringe Pumps Firmware Version: V3.919 Infusion Rate 60 50 40 30 20 10 0 0 10 20 30 40 50 60 70 80 90 Time “WHAT’S YOUR APPLICATION?”™ WARNING NOT FOR CLINICAL USE ON HUMANS Publication #1240-01 Revision 18 V3.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ Quick Start Instructions Assumes that the pump was not previous programmed with a multiple Phase Pumping Program. • • • Plug in the pump. Press the power switch to turn on power. Press any key to stop the display from blinking. Setup Pumping Parameters To Change Numbers: • Use the up arrow keys to increment individual digits.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ Table of Contents 1. GENERAL INFORMATION .............................................................................................. 1 1.1 1.2 1.3 1.4 2. WARNINGS ! AND CAUTIONS ! .............................................................................. 1 DISCLAIMER .................................................................................................................... 1 WARRANTY .............................
New Era Pump Systems Inc. 6.6 6.7 6.8 7. Model NE-4000 Multi-Phaser™ VOLUME DISPENSED..................................................................................................... 12 RESUMING WHEN PAUSED ........................................................................................... 13 PUMP STALLED ............................................................................................................. 13 SETUP CONFIGURATION ........................................................
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 9.2.1 RS-232 GENERAL SYNTAX LEGEND ....................................................................... 31 9.2.2 RS-232 PROTOCOL: BASIC MODE .......................................................................... 32 9.2.3 RS-232 PROTOCOL: SAFE MODE ............................................................................ 32 9.2.4 RS-232 PROTOCOL: BASIC AND SAFE MODE COMMON SYNTAX .......................... 33 9.2.
www.SyringePump.com New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ 1. General Information Thank you for purchasing the NE-4000 Multi-Phaser™ Programmable Syringe Pump. With the NE-4000 syringe pump you will be able to perform simple infusions or implement a complex automated dispensing system. Please familiarize yourself with the NE-4000’s operation by reading this user's manual. For future reference, record the serial number, located on the rear of the pump, and the date of purchase.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ A return authorization number must be obtained from New Era Pump Systems Inc. before returning a unit for repair. Warranty covered repairs will not be performed without a return authorization number. At the option of New Era Pump Systems Inc., a defective unit will be either repaired or replaced.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 2.1 Glossary of Terminology and Concepts When a device has as many features as the NE-4000, understanding its operation could be a daunting task at first. By understanding the key concepts and terminology used in this manual, the operation of the NE-4000 will become quite intuitive. Every effort has been made to design the NE-4000 with a consistent and intuitive user interface.
www.SyringePump.com Parts of a Syringe New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ Plunger Flange Plunger Barrel Flange Barrel Terminology Momentary Press: A quick press, less than 1 second, and then release of a key on the keypad. Display Blink: A momentary blanking of the LCD display. This indicates that the new data entered by the user is valid and has been stored. Program Entry Mode: The mode where the Program Phase and Program function are selected and modified.
www.SyringePump.com New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ 3. Setup ♦ Place the pump on a stable surface. ♦ Plug the round connector end of the supplied power supply adapter into the power plug located on the lower right of the pump's rear. See section 10, Logic Interface: TTL Input and Output, for a diagram of the rear of the pump. Plug the other end of the power supply adapter into an appropriate electrical outlet.
www.SyringePump.com New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ 5.1 Entering Values When applicable, values can be changed by either displaying the current value, then using the arrow keys, or from a computer connected to the pump. The new value will be stored in the pump’s non-volatile memory, meaning that the new value will not be lost the next time that power is applied to the pump.
www.SyringePump.com 5.4 Arrow and Decimal Point Keys New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ Each of the four digits in the display is associated with the up arrow key directly below it. When applicable, the arrow key is used to increment the value of that digit, or advance to the next selection in a list of functions or settings. Each press of an up arrow key will increase the digit by 1, up to 9, and then back to 0.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 5.6.2 Program Entry Mode While the Pumping Program is stopped, “Program Entry Mode” can be entered by pressing and holding the ‘Rate’ key. Release the key when the display shows the current Program Phase number: indicates the current Program Phase number.
www.SyringePump.com New Era Pump Systems Inc. High Level: Withdraw Model NE-4000 Multi-Phaser™ Infuse 5.9 ‘Start’/’Stop’ Key The ‘Start/Stop’ key starts or stops the Pumping Program’s operation. Pressing this key switches between the Pumping Program operating and the Pumping Program paused. When the ‘Start/Stop’ key is pressed before the completion of a Program, the motor is stopped and the Pumping Program will be paused.
www.SyringePump.com 5.13 Special Power-Up Functions New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ The following special functions are accessed by pressing the relevant key, while turning on power to the pump. 5.13.1 Firmware Version Display To display the pump’s firmware version, press the left-most up-arrow key ( / ) while turning on power to the pump. The display will show: clear the display. n.nn , where ‘n.nn’ is the firmware version number. Pressing any key will 5.13.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ A communications time-out alarm occurred with an attached computer while operating in the “Safe Communications Mode”. This most likely indicates that the RS-232 cable was detached or the communication program on the computer has ended without turning off “Safe Communications Mode”. n An error was detected during power up, where ‘n’ indicates the error.
New Era Pump Systems Inc. From 0.1 to 14.0 mm From 14.01 to 50.0 mm www.SyringePump.com Model NE-4000 Multi-Phaser™ Syringes smaller than 10 mL: Volume units are ‘µL’ Syringes greater than or equal to 10 mL: Volume units are ‘mL’ 6.1.2 Changing Volume Units The Volume Units used for accumulated volumes and the “Volume to be Dispensed” settings can be changed to either ‘mL’ or ‘µL’. Volume Units can only be changed while the Pumping Program is stopped.
www.SyringePump.com New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ The volume is accumulated separately for infusion and withdrawal. When the pump changes direction, the “Volume Dispensed” changes to the accumulated volume for the current pumping direction. The “Volume Dispensed” accumulations for infusion and withdrawal are reset to 0 when: A) With the pump stopped, pressing and holding any up arrow key while displaying the “Volume Dispensed”.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ nnnn RS-232 pump network baud rate, where ‘nnnn’ indicates the baud rate. Otherwise, the current communications mode will be displayed: , , or Communications Mode. Reciprocating, Dual Pump, or Alternating 7.1 Power Failure Mode n Setting: ‘0’ = Disabled, ‘1’ = Enabled.
www.SyringePump.com Model NE-4000 Multi-Phaser™ 7.4 TTL I/O Operational Trigger Default Configuration New Era Pump Systems Inc. aa Configures the default mode of the TTL I/O ‘Operational Trigger’ (pin 2) that will control the Pumping Program’s operation. This default setting can be overridden within a Pumping Program. (See sec. 10.1, TTL I/O Operational Controls).
www.SyringePump.com Model NE-4000 Multi-Phaser™ 7.6 Pump Motor Operating TTL Output Configuration New Era Pump Systems Inc. n Configures the functionality of the 'Pump Motor Operating' TTL output pin (TTL pin 7). Settings: 0: Sets the output to logic high only when the motor is operating (pumping).
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ To change the communications mode: With the network address displayed [Ad:nn], press the left-most arrow key to enter the communications mode menu. Pressing any arrow key will scroll through the menu selections: Address Mode: Default communications with a computer mode. Reciprocating Pumps. Sends Start/Stop, Pumping rate and reverse pumping direction to an attached secondary pump. Reciprocating Pumps.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ When in “Program Entry Mode”, with the display showing the Program Phase number, pressing the ‘Volume’/’Program Function’ key will display the current “Program Function” for this Phase. If the current function is ‘RATE’, then a pumping infusion or withdrawal can be setup for this Phase. To change the “Program Function” selected, use the arrow keys to scroll through the functions until the required function is displayed.
www.SyringePump.com New Era Pump Systems Inc. Editing Function PH In dE Model NE-4000 Multi-Phaser™ Description Phase select Insert Phase Delete Phase When the required editing function is displayed, press the ‘Rate’/’Program Phase #’ key before the 2 second time out. After the time out, or with any other key press, the function will be canceled. If ‘Insert’ or ‘Delete’ was selected, the Pumping Program will be edited. While the Program is being edited, the display will show [BUSY].
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 8.3.4 ‘DECr’: Decrement Rate Function The decrement function subtracts the specified rate from the current pumping rate. For a full description, see section 8.3.3, ‘InCr’: Increment Rate Function. 8.3.5 ‘StoP’: Stop Pumping Operation and End the Program Stops the pumping operation and stops the Pumping Program. The Pumping Program will begin at Phase 1 when started again.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 8.3.9 ‘LP:ST’: Define Starting Phase of Loop Defines the start of a Program loop. For a full description of Program looping, see sec. 8.3.11, ‘LP:nn’: 8.3.10 ‘LP:EN’: Define Continuous Loop End Loops to the most recently executed, unpaired, ‘loop start’ Phase, or Phase 1 if none. This function allows a section of the Program to be repeated continuously. For a full description of Program looping, see sec. 8.3.11, ‘LP:nn’: . 8.3.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 8.3.13 'IF:nn': Jump to Phase If External Trigger nn The ‘IF’ function conditionally alters the Pumping Program’s execution based on an external signal. When executed, if the TTL I/O Program Input pin (pin 6) is low level, then the Pumping Program continues operation with Phase number ‘nn’. Otherwise, the Pumping Program continues operation with the next Phase. 8.3.
www.SyringePump.com New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ The Trigger Event Trap is a one-time function. After triggering an Event Trap, the Trigger Event Trap is cleared. The Trigger Event function will not affect the current trigger configuration. 8.3.19 'OUt.n': Set TTL Output Pin n Set ‘Program Output’ TTL I/O output (pin 5) to level ‘n’. If ‘n’ = 0, the output pin will be set low. If ‘n’ = 1, the output pin will be set high. 8.3.20 'bEEP': Beep Sounds a short beep. 8.
www.SyringePump.com New Era Pump Systems Inc. Phase 5 Function PS:90 Phase 6 Function LP:03 Phase 7 Function BEEP Phase 8 Function PS:30 Phase 9 Function RATE Rate 750 mL/hr Volume 2.25 mL Direction Infuse Phase 10 Function RATE Rate 750 mL/hr Volume 0.25 mL Direction Withdraw Phase 11 Function LP:EN Model NE-4000 Multi-Phaser™ 8.4.3 Example 3: Ramping the Flow Rate ml/hr Rate Phases 2-4 Phases 5-8 250 Phases 9-11 200 150 0 Time Note: Graph is representative only.
www.SyringePump.com New Era Pump Systems Inc. Phase 10 Function INCR Phase 11 Function LP:50 Phase 12 Function JP:02 Rate 1.0 Volume 0.1 mL Model NE-4000 Multi-Phaser™ Direction Infuse Withdraw (ml/hr) Infuse 8.4.
New Era Pump Systems Inc. Phase 12 Function LP:03 Phase 13 Function RATE Phase 14 Function BEEP Phase 15 Function PS:00 Phase 16 Function LP:EN www.SyringePump.com Rate 900.0 mL/hr Volume 17.25 mL Model NE-4000 Multi-Phaser™ Direction Withdraw 8.4.
www.SyringePump.com New Era Pump Systems Inc. Phase 7 Function EV:01 Phase 8 Function LP:ST Phase 9 Function INCR Phase 10 Function LP:14 Phase 11 Function RATE Rate 1.0 Volume 0.25 mL Direction Infuse Rate 25.0 mL/hr Volume 0.0 mL (off) Direction Infuse Model NE-4000 Multi-Phaser™ 8.4.
New Era Pump Systems Inc. Phase 7 Function PS:60 Phase 8 Function LP:60 Phase 9 Function LP:05 Phase 10 Function LP:12 Phase 11 Function JP:01 www.SyringePump.com Model NE-4000 Multi-Phaser™ 8.4.7 Example 7: Sub-Programs This example shows some of the flexibilities provided by the Program Selection functions. The Pumping Program starts by refilling the syringe with 50 mL at a fast pumping rate (Phase 1), then the Pumping Program pauses for user sub-program selection (Phase 3).
New Era Pump Systems Inc. Phase 13 www.SyringePump.com Model NE-4000 Multi-Phaser™ Function JP:01 8.4.8 Example 8: Dispensing with Complex Synchronization Restart on Event Trigger or 10 seconds Withdraw Infuse Infuse until Event Trigger Repeat if Program Input low :01 TTL High TTL Low TTL Program Ouput :10 :10 Event Trigger Event Trigger This example demonstrates a complex interaction with external equipment, such as synchronizing with another syringe pump.
New Era Pump Systems Inc. Phase 10 Function PS:10 Phase 11 Function ET:01 Phase 12 Function PS:10 Phase 13 Function JP:01 www.SyringePump.com Model NE-4000 Multi-Phaser™ 8.4.9 Example 9: Automatic Refill While a foot switch is held, dispense continuously, starting with a 1.5 mL bolus. When the foot switch is released, the syringe will refill to the volume that was dispensed. In the pump’s general setup, set the TTL Trigger to “Foot Switch Hold” mode (TR:FH).
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 9.2 RS-232 Protocol When the pump is used in a multi-pump network configuration, precede each command with a pump address. Pumps will ignore all commands that do not have their defined network address. If the network address is not specified in the command, the address will default to 0. After a command is sent to the pump, the pump will not accept any further communications until the current command has been processed.
New Era Pump Systems Inc. www.SyringePump.com <> [] {} | λ "" Model NE-4000 Multi-Phaser™ Non-terminal syntax expansion Optional syntax Required syntax Or. Choose one of the syntax options. None. Syntax expands to nothing (lambda production). Description of syntax expansion 9.2.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 9.2.
New Era Pump Systems Inc. OOR COM IGN www.SyringePump.com Model NE-4000 Multi-Phaser™ Command data is out of range Invalid communications packet received Command ignored due to a simultaneous new Phase start When an alarm occurs, the alarm must be acknowledged before any data is changed or the pump is started. Alarms are acknowledged by the user clearing the alarm message on the keypad, or the alarm status being sent in response to any valid RS-232 command.
www.SyringePump.com New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ => Rate Data Functions When a Phase’s function is set to a “Rate Data Function”, use the ‘RAT’, ‘VOL’, and ‘DIR’ commands to setup the pumping parameters. RAT FIL INC DEC STP PAS PAS PRI PRL LPS LPE LOP JMP IF EVN EVS EVR CLD TRG BEP OUT Pumping rate. ‘RATE’ Fill syringe to dispensed volume. ‘FILL’ Increment rate. ‘INCR’ Decrement rate. ‘DECR’ Non-Rate Control Functions Stop pump.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ Set/query volume to be dispensed: Applicable only with “Rate Data Functions”. Can only be set when the Pumping Program is not operating. The volume units are set according to the current syringe diameter setting. Do not send the volume units when setting the volume. Example: VOL 12.45 Sets the current phase “Volume to be Dispensed” to 12.45.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ VOLUME DISPENSED DIS Queries volume dispensed only. Set not applicable. Response: I W Where: “I “ refers to the infusion volume dispensed, and “W ” refers to the withdrawn volume. CLEAR VOLUME DISPENSED CLD { INF | WDR } Sets the Infused or withdrawn volume dispensed to 0. Command is only valid while the Pumping Program is not operating. Query is not applicable.
www.SyringePump.com New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ TTL I/O DIRECTIONAL CONTROL INPUT SETUP DIN [ 0 | 1 ] Set/query directional control input setup Settings => 0 = Falling edge: Infuse, Rising edge Withdraw Same as "dr:rE" setting from the keypad. Use this setting with the CBL-TTL-1, reciprocating pump cable, to create a 2 pump continuous infusion system 1 = Falling edge: Withdraw, Rising edge Infuse Same as "dr:dU" setting from the keypad.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ BUZZER BUZ [ 0 | { 1 [ < n > ] } ] Sets / queries buzzer Set: 0 = Turn buzzer off; 1 = Turn buzzer on if specified If = 0, buzzer beeps continuously, otherwise buzzer beeps times if not specified, buzzer sounds continuously Query response: { 0 | 1 } 0 = Buzzer off 1 = Buzzer is on continuously or beeping. 9.4.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ FIRMWARE VERSION QUERY VER Response: NEV . where ‘.‘ is current firmware version number. Set is not applicable. MASTER PROGRAM RESET * RESET Clears program memory and resets communication parameters to Basic mode and address 0. This is a special system command that will be accepted by the pump regardless of its current address. 9.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 10. Logic Interface: TTL Input and Output New Era Pump Systems Inc. WWW.SYRINGEPUMP.COM (631) 249-1392 Farmingdale, NY info@syringepump.com 4000 Pin 1 12 1.0 Pin 9 Figure 2: Rear of Pump On the rear of the pump is a DB-9 connector, below the ‘TTL-I/O’ label, which is used for TTL I/O. The logic signals on this connector permit bi-directional control with external equipment.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ Pin # Definition Type Function 1 Vcc (5V) Reference Logic high reference. Power on indicator.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ Level Control: Falling edge stops/pauses the Pumping Program, Rising edge starts the Pumping Program. This configuration can be used with a contact closure timer or in an automation setup, allowing logic level control over the operation of the pump. Start Only: Falling edge starts the Pumping Program. This configuration only allows the starting of the Pumping Program.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 11. Appendix 11.1 RS-232 Command Summary => DIA [ < float > ] Syringe inside diameter PHN [ < phase data > ] Program Phase number FUN [ < phase function > ] Program Phase function < phase function > => RAT Pumping rate. ‘RATE’ FIL Fill syringe to volume dispensed. ‘FILL’ INC Increment rate. ‘INCR’ DEC Decrement rate. ‘DECR’ STP Stop pump. ‘STOP’ JMP Jump to Program Phase.
www.SyringePump.com 11.2 RS-232 Pump Network Connector Wiring New Era Pump Systems Inc. Model NE-4000 Multi-Phaser™ RS-232 To Network To Computer RCV from network TXD to computer TXD to network RCV from computer PC Com Port Connectors 25 Pin 9 Pin 3 - Receive 2 - Receive Connect to pump TXD 2 - Transmit 3 - Transmit Connect to pump RCV 9 - Ground 5 - Ground Connect to pump GND 11.3 Accessories 11.3.1 ANA-BOX™ Part #: ADPT-ANABOX, Analog voltage control interface.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ This cable is attached to two NE-4000 syringe pumps via their RS-232 connectors. In this setup, with the pumps configured for this operation, one pump acts as the Master controller. With the Master pump programmed with a continuous infusion program, the other pump will always be pumping in the opposite direction. With proper plumbing, this will create a continuous infusion system.
New Era Pump Systems Inc. www.SyringePump.com Model NE-4000 Multi-Phaser™ 11.5 Specifications 11.5.1 Mechanical & Electrical Syringe sizes: Number of syringes: Motor type: Motor steps per revolution: Microstepping: Advance per step: Motor to drive screw ratio: Drive screw pitch: Power connector: Voltage at DC connector: Amperage: Power supply type: Power supply output rating: Dimensions: Weight: Up to 60 mL. 140 mL partially filled 2 Step motor 200 1/8 to 1/2 depending on motor speed 0.41852679 µm to 1.
www.SyringePump.com 11.7 Syringe Diameters and Rate Limits New Era Pump Systems Inc. Syringe Syringe Inside Maximum Manufacturer (mL) Diameter Rate (all names ™) (mm) (mL/hr) B-D 1 4.699 188.1 3 8.585 627.9 5 11.99 1224 10 14.43 1774 20 19.05 3091 30 21.59 3971 60 26.59 6023 HSW 1 4.69 187.4 Norm-Ject 3 9.65 793.4 5 12.45 1320 10 15.9 2153 20 20.05 3425 30 22.9 4468 50 29.2 7264 Monoject 1 5.74 280.7 3 8.941 681.1 6 12.7 1374 12 15.72 2105 20 20.12 3449 35 23.52 4713 60 26.64 6046 140 38 9999 Terumo 1 4.
