Certifications 2

SDS No.: 128186 V002.0
Metylan Ovalit TM
Page 10 of 14
Carcinogenicity
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous components
CAS-No.
Result
Route of
application
Exposure
time /
Frequency
of treatment
Species
Sex
Method
Isothiazolinone mixture
3:1 (CIT/MIT)
55965-84-9
not carcinogenic
oral: drinking
water
2 y
daily
rat
male/female
OECD Guideline 453
(Combined Chronic
Toxicity /
Carcinogenicity
Studies)
Reproductive toxicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result / Value
Test type
Route of
application
Species
Method
2-methylisothiazol-3(2H)-
one
2682-20-4
NOAEL P 200 ppm
NOAEL F1 200 ppm
NOAEL F2 200 ppm
Two
generation
study
oral:
drinking
water
rat
OECD Guideline 416 (Two-
Generation Reproduction
Toxicity Study)
Isothiazolinone mixture
3:1 (CIT/MIT)
55965-84-9
NOAEL P 30 ppm
NOAEL F1 300 ppm
NOAEL F2 300 ppm
Two
generation
study
oral:
drinking
water
rat
OECD Guideline 416 (Two-
Generation Reproduction
Toxicity Study)
STOT-single exposure:
No data available.
STOT-repeated exposure::
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result / Value
Route of
application
Exposure time /
Frequency of
treatment
Species
Method
2-methylisothiazol-3(2H)-
one
2682-20-4
NOAEL 60 mg/kg
oral: gavage
90 d
daily
rat
OECD Guideline 408
(Repeated Dose 90-Day
Oral Toxicity in Rodents)
Isothiazolinone mixture
3:1 (CIT/MIT)
55965-84-9
NOAEL 16,3 mg/kg
oral:
drinking
water
90 d
daily
rat
OECD Guideline 408
(Repeated Dose 90-Day
Oral Toxicity in Rodents)
Isothiazolinone mixture
3:1 (CIT/MIT)
55965-84-9
NOAEL 0.34 mg/m3
inhalation:
aerosol
90 d
6 h/d, 5 d/w
rat
OECD Guideline 413
(Subchronic Inhalation
Toxicity: 90-Day)
Isothiazolinone mixture
3:1 (CIT/MIT)
55965-84-9
NOAEL 2,625 mg/kg
dermal
90 d
6 h/d
rat
EPA OPP 82-3
(Subchronic Dermal
Toxicity 90 Days)
Aspiration hazard:
No data available.