SDS

13
Reproductive toxicity :
- Graphite :
- Copper : In reproductive toxicity with rats, there were no effects considered (up to 1500 ppm). (OECD TG 416, GLP)
- Aluminum : No reproduction, breeding and early post-natal developmental toxicity was observed in rats at 1000 mg/kg bw for males
and females. (OECD TG 422, GLP)(Aluminum chloride; read across)
- Lithium hexafluorophosphate(1-) : In the two-generation reproductive toxicity with rats, no effects observed on reproductive
toxicity. (male/female)(OECD Guideline 416, GLP)(OECD Guideline 414)(Information on major hydrolysis product of the
registered substance (released rapidly on contact with water/moisture))
- Boehmite (Al(OH)O) : No reproduction, breeding and early post-natal developmental toxicity was observed in rats at 1000 mg/kg
body weight for males and females.(OECD Guideline 422, GLP)
- Carbon black : No adverse effects on the reproductive function are expected.(OECD TG 414)
- Chromium : In the 90 days inhalation toxicity study using rat, there were no effects on clinical signs, mortality.(OECD TG 413)
- Ethylbenzene : There were no adverse effects on reproductive or developmental endpoints at dose levels up to 500 ppm EB in this
guideline two-generation rat inhalation study. OECD TG 416, GLP); Results of prenatal Developmental Toxicity tests for rats, litter
size was comparable between the treated and control dose groups, while a statistically significant dose-related reduction in fetal
weights were noted in the 1000 and 2000 ppm dose groups. Visceral malformations occurred in one or few fetuses from the 100, 1000
and 2000 ppm exposure groups, without a clear dose relationship and no statistical significance. NOAEC = 2000ppm (OECD
Guideline 414)
Specific target organ toxicity (single exposure) :
- Fe : If inhaled, iron is a local irritant to the lung and gastrointestinal tract.
- Copper : All animals showed expected gains in bodyweight over the study period and there were no abnormalities
noted at necropsy. (OECD TG 423, GLP)
- Aluminum : In test using rats, Clinical signs of depression, laboured respiration, piloerection and hunched
appearance was noted at the highest dose 15900 mg/kg. Macroscopic examination at the end of the observation
period did not reveal any aluminum-related changes of the internal organs of the aluminum treated animals
compared to the control group. (OECD TG 401)(Fumed alumina; read across)
- Lithium hexafluorophosphate(1-) : Clinical signs observed during the study period were lethargy, hunched posture,
uncoordinated movements, piloerection at 300 mg/kg, hunched posture, piloerection at 50 mg/kg. The surviving
animals had recovered from the symptoms by Day 3.(OECD Guideline 423, GLP)
- Polyethylene : No test substance-related toxic effects were observed in an acute oral toxicity study with rats.
- Carbon black : No effect on endothelins or blood pressure was observed after exposure to carbon black. There
were also no effects on body temperature and activity of the animals.
- Nickel; Raney nickel : In the acute oral toxicity using rat, there were no effects on clinical signs, systemic
toxicity.(OECD Guideline 401, GLP)
- Chromium : In the acute oral toxicity using rat, salivation increased among all animals 15 minutes after
administration of the test substance, and lasted about 8 hours. (OECD TG 420, GLP)
- Ethylbenzene : In acute oral, inhalation, dermal toxicity study with rats, adverse effects were not observed related
to acute toxicity.
Specific target organ toxicity (repeat exposure) :
- Fe : Rats were exposed to metallic iron as carbonyl iron via their feed (2.5%) for 2, 4, 6, or 9 weeks. This resulted in
a strong increase of non-heme iron in the liver and clear lipid peroxidation in the liver and the mucosa of the
duodenum. No evidence for DNA breakage were found. What follows is the original abstract of the publication.
(carbonyl iron)
- Copper : In test with rats for 92 days, there were no mortalities or signs of clinical toxicity observed in any of the test
species during the duration of the study. Opthalmoscopic examinations revealed no abnormalities at any dose level
tested. At gross pathology, significant decreases in heart and kidney weight were noted in the high dose males in
the thymus and kidneys of high dose females. (GLP)
- Aluminum : On occasion workers chronically exposed to aluminum-containing dusts or fumes have developed
severe pulmonary reactions including fibrosis, emphysema and pneumothorax.
- Lithium hexafluorophosphate(1-) : According to expert review of fluoride intake and effects on human health, fluoride
intake in drinking water at levels close to or above 4 mg/l is associated with dental fluorosis and perhaps also bone
fluorosis and/or weakening.; Damage to dental enamel recorded: especially notable in young animals, which also
showed atrophy of respiratory organs/tissues with local oedema of bronchial mucosa. Older animals showed
peribronchial hyperplasia. Animals around 1 year in age showed cavity formation in their bones.(Information on
major hydrolysis product of the registered substance (released rapidly on contact with water/moisture))(OECD
Guideline 412)
- Polyethylene : No significant adverse effects were observed in subchronic (90-day) oral toxicity study with rats and
dogs