Datasheet

MSDS-No.: 427527
V002.1
LOCTITE 454
Page 8 of 11
Skin corrosion/irritation:
Hazardous components
CAS-No.
Result
Exposure
time
Species
Method
Ethyl 2-cyanoacrylate
7085-85-0
slightly irritating
24 h
rabbit
OECD Guideline 404 (Acute
Dermal Irritation / Corrosion)
Serious eye damage/irritation:
Hazardous components
CAS-No.
Result
Exposure
time
Species
Method
Ethyl 2-cyanoacrylate
7085-85-0
irritating
72 h
rabbit
OECD Guideline 405 (Acute
Eye Irritation / Corrosion)
Respiratory or skin sensitization:
Hazardous components
CAS-No.
Result
Test type
Species
Method
Ethyl 2-cyanoacrylate
7085-85-0
not sensitising
guinea pig
Hydroquinone
123-31-9
sensitising
Guinea pig
maximisat
ion test
guinea pig
Germ cell mutagenicity:
Hazardous components
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
Ethyl 2-cyanoacrylate
7085-85-0
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
negative
bacterial reverse
mutation assay (e.g
Ames test)
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Bis(2-hydroxy-3-tert-
butyl-5-
methylphenyl)methane
119-47-1
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Hydroquinone
123-31-9
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
EU Method B.13/14
(Mutagenicity)
Repeated dose toxicity
Hazardous components
CAS-No.
Result
Route of
application
Exposure time /
Frequency of
treatment
Species
Method
Hydroquinone
123-31-9
NOAEL=>= 250
mg/kg
oral: gavage
14 days 5 days/week.
12 doses
rat
OECD Guideline 407
(Repeated Dose 28-Day Oral
Toxicity in Rodents)
SECTION 12: Ecological information
General ecological information:
Biological and Chemical Oxygen Demands (BOD and COD) are insignificant.
The mixture is classified based on the available hazard information for the ingredients as defined in the classification criteria
for mixtures for each hazard class or differentiation in Annex I to Regulation 1272/2008/EC. Relevant available
health/ecological information for the substances listed under Section 3 is provided in the following.
12.1. Toxicity
Ecotoxicity:
Do not empty into drains / surface water / ground water.