Datasheet

MSDS-No.: 427527
V002.1
LOCTITE 454
Page 7 of 11
10.2. Chemical stability
Stable under recommended storage conditions.
10.3. Possibility of hazardous reactions
See section reactivity
10.4. Conditions to avoid
Stable under normal conditions of storage and use.
10.5. Incompatible materials
See section reactivity
10.6. Hazardous decomposition products
None if used for intended purpose.
SECTION 11: Toxicological information
11.1. Information on toxicological effects
General toxicological information:
The mixture is classified based on the available hazard information for the ingredients as defined in the classification criteria
for mixtures for each hazard class or differentiation in Annex I to Regulation 1272/2008/EC. Relevant available
health/ecological information for the substances listed under Section 3 is provided in the following.
Oral toxicity:
Cyanoacrylates are considered to have relatively low toxicity. Acute oral LD50 is >5000mg/kg (rat). It is almost impossible
to swallow as it rapidly polymerises in the mouth.
Inhalative toxicity:
May cause respiratory irritation.
Prolonged exposure to high concentrations of vapours may lead to chronic effects in sensitive individuals
In dry atmosphere with < 50% humidity, vapours may irritate the eyes and respiratory system
Skin irritation:
Causes skin irritation.
Bonds skin in seconds. Considered to be of low toxicity: acute dermal LD50 (rabbit)>2000mg/kg
Due to polymerisation at the skin surface allergic reaction is unlikely to occur
Eye irritation:
Causes serious eye irritation.
Liquid product will bond eyelids. In a dry atmosphere (RH<50%) vapours may cause irritation and lachrymatory effect
Acute oral toxicity:
Hazardous components
CAS-No.
Value
type
Value
Route of
application
Exposure
time
Species
Method
Ethyl 2-cyanoacrylate
7085-85-0
LD50
> 5.000 mg/kg
oral
rat
OECD Guideline 401 (Acute
Oral Toxicity)
Hydroquinone
123-31-9
LD50
367 mg/kg
oral
rat
OECD Guideline 401 (Acute
Oral Toxicity)
Acute inhalative toxicity:
Hazardous components
CAS-No.
Value
type
Value
Route of
application
Exposure
time
Species
Method
Acute dermal toxicity:
Hazardous components
CAS-No.
Value
type
Value
Route of
application
Exposure
time
Species
Method
Ethyl 2-cyanoacrylate
7085-85-0
LD50
> 2.000 mg/kg
dermal
rabbit
OECD Guideline 402 (Acute
Dermal Toxicity)