Datasheet

MSDS-No.: 450730
V004.1
LOCTITE 648
Page 12 of 17
Acute dermal toxicity:
Hazardous components
CAS-No.
Value
type
Value
Route of
application
Exposure
time
Species
Method
Acrylic acid
79-10-7
LD50
640 mg/kg
dermal
rabbit
BASF Test
Hydroxypropyl
methacrylate
27813-02-1
LD50
> 5.000 mg/kg
dermal
rabbit
Maleic acid
110-16-7
LD50
1.560 mg/kg
dermal
rabbit
Methacrylic acid
79-41-4
Acute
toxicity
estimate
(ATE)
500 mg/kg
dermal
Expert judgement
Methacrylic acid
79-41-4
LD50
500 - 1.000
mg/kg
rabbit
Dermal Toxicity Screening
Skin corrosion/irritation:
Hazardous components
CAS-No.
Result
Exposure
time
Species
Method
Acrylic acid
79-10-7
highly corrosive
3 min
rabbit
OECD Guideline 404 (Acute
Dermal Irritation / Corrosion)
Cumene hydroperoxide
80-15-9
corrosive
rabbit
Draize Test
Methacrylic acid
79-41-4
Category 1A (corrosive)
4 h
rabbit
OECD Guideline 404 (Acute
Dermal Irritation / Corrosion)
Serious eye damage/irritation:
Hazardous components
CAS-No.
Result
Exposure
time
Species
Method
Acrylic acid
79-10-7
corrosive
21 d
rabbit
BASF Test
Respiratory or skin sensitization:
Hazardous components
CAS-No.
Result
Test type
Species
Method
Acrylic acid
79-10-7
not sensitising
Skin
painting
test
guinea pig
Methacrylic acid
79-41-4
not sensitising
Buehler
test
guinea pig
Buehler test
Germ cell mutagenicity:
Hazardous components
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
2-Hydroxyethyl
methacrylate
868-77-9
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
positive
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Acrylic acid
79-10-7
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
Cumene hydroperoxide
80-15-9
positive
bacterial reverse
mutation assay (e.g
Ames test)
without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Cumene hydroperoxide
80-15-9
negative
dermal
mouse