Certifications 2

MSDS-No.: 173097
V004.0
LOCTITE 640
Page 12 of 17
Serious eye damage/irritation:
Hazardous components
CAS-No.
Result
Exposure
time
Species
Method
2,2'-Ethylenedioxydiethyl
dimethacrylate
109-16-0
not irritating
rabbit
OECD Guideline 405 (Acute
Eye Irritation / Corrosion)
Acrylic acid
79-10-7
corrosive
21 d
rabbit
BASF Test
Methacrylic acid
79-41-4
Category I
rabbit
Draize Test
Respiratory or skin sensitization:
Hazardous components
CAS-No.
Result
Test type
Species
Method
2,2'-Ethylenedioxydiethyl
dimethacrylate
109-16-0
sensitising
Mouse
local
lymphnod
e assay
(LLNA)
mouse
OECD Guideline 429 (Skin
Sensitisation: Local Lymph
Node Assay)
Acrylic acid
79-10-7
not sensitising
Skin
painting
test
guinea pig
not specified
Methacrylic acid
79-41-4
not sensitising
Buehler
test
guinea pig
OECD Guideline 406 (Skin
Sensitisation)
Germ cell mutagenicity:
Hazardous components
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
2,2'-Ethylenedioxydiethyl
dimethacrylate
109-16-0
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
negative
in vitro mammalian
cell micronucleus
test
with and without
OECD Guideline 487 (In vitro
Mammalian Cell
Micronucleus Test)
Hydroxypropyl
methacrylate
27813-02-1
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Hydroxypropyl
methacrylate
27813-02-1
negative
oral: gavage
rat
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
Acrylic acid
79-10-7
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
not specified
Cumene hydroperoxide
80-15-9
positive
bacterial reverse
mutation assay (e.g
Ames test)
without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Cumene hydroperoxide
80-15-9
negative
dermal
mouse
not specified
Methacrylic acid
79-41-4
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Methacrylic acid
79-41-4
negative
inhalation
mouse
OECD Guideline 478 (Genetic
Toxicology: Rodent Dominant
Lethal Test)
Carcinogenicity:
Hazardous components
CAS-No.
Result
Species
Sex
Exposure
timeFrequenc
y of treatment
Route of
application
Method
Hydroxypropyl
methacrylate
27813-02-1
rat
male
2 years (102
weeks)
6 hours/day, 5
days/week
inhalation
OECD Guideline 451
(Carcinogenicity Studies)