Certifications 2

SDS No.: 444476 V003.0
LOCTITE SI 5990 known as Loctite SI 5990 40 ML EDFN
Page 10 of 16
Respiratory or skin sensitization:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Test type
Species
Method
octamethylcyclotetrasilox
ane
556-67-2
not sensitising
Guinea pig maximisation
test
guinea pig
OECD Guideline 406 (Skin Sensitisation)
Dodecamethylcyclohexasi
loxane
540-97-6
not sensitising
Guinea pig maximisation
test
guinea pig
OECD Guideline 406 (Skin Sensitisation)
Germ cell mutagenicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
octamethylcyclotetrasilox
ane
556-67-2
negative
bacterial gene
mutation assay
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
octamethylcyclotetrasilox
ane
556-67-2
negative
in vitro mammalian
chromosome
aberration test
with and without
equivalent or similar to OECD
Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
octamethylcyclotetrasilox
ane
556-67-2
negative
mammalian cell
gene mutation assay
with and without
equivalent or similar to OECD
Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Dodecamethylcyclohexasi
loxane
540-97-6
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Dodecamethylcyclohexasi
loxane
540-97-6
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Carcinogenicity
No data available.
Reproductive toxicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result / Value
Test type
Route of
application
Species
Method
octamethylcyclotetrasilox
ane
556-67-2
NOAEL P 300 ppm
NOAEL F1 300 ppm
two-
generation
study
inhalation
rat
equivalent or similar to
OECD Guideline 416 (Two-
Generation Reproduction
Toxicity Study)
Dodecamethylcyclohexasi
loxane
540-97-6
NOAEL P 1.000 mg/kg
NOAEL F1 1.000 mg/kg
screening
oral: gavage
rat
OECD Guideline 422
(Combined Repeated Dose
Toxicity Study with the
Reproduction /
Developmental Toxicity
Screening Test)
STOT-single exposure:
No data available.