Certifications 2

SDS No.: 173255 V003.4
LOCTITE 4062
Page 9 of 13
Germ cell mutagenicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
Ethyl 2-cyanoacrylate
7085-85-0
negative
bacterial reverse
mutation assay (e.g
Ames test)
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Ethyl 2-cyanoacrylate
7085-85-0
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Ethyl 2-cyanoacrylate
7085-85-0
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Hydroquinone
123-31-9
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
equivalent or similar to OECD
Guideline 471 (Bacterial
Reverse Mutation Assay)
Hydroquinone
123-31-9
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Hydroquinone
123-31-9
positive
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Hydroquinone
123-31-9
positive
intraperitoneal
mouse
equivalent or similar to OECD
Guideline 474 (Mammalian
Erythrocyte Micronucleus
Test)
Hydroquinone
123-31-9
negative
oral: gavage
rat
equivalent or similar to OECD
Guideline 478 (Genetic
Toxicology: Rodent Dominant
Lethal Test)
Hydroquinone
123-31-9
positive
intraperitoneal
mouse
equivalent or similar to OECD
Guideline 483 (Mammalian
Spermatogonial Chromosome
Aberration Test)
Carcinogenicity
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous components
CAS-No.
Result
Route of
application
Exposure
time /
Frequency
of treatment
Species
Sex
Method
Hydroquinone
123-31-9
carcinogenic
oral: gavage
103 w
5 d/w
rat
male/female
equivalent or similar
OECD Guideline 453
(Combined Chronic
Toxicity /
Carcinogenicity
Studies)
Hydroquinone
123-31-9
carcinogenic
oral: gavage
103 w
5 d/w
mouse
female
equivalent or similar
OECD Guideline 453
(Combined Chronic
Toxicity /
Carcinogenicity
Studies)
Reproductive toxicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result / Value
Test type
Route of
application
Species
Method
Hydroquinone
123-31-9
NOAEL P 15 mg/kg
NOAEL F1 150 mg/kg
NOAEL F2 150 mg/kg
Two
generation
study
oral: gavage
rat
EPA OTS 798.4700
(Reproduction and Fertility
Effects)