Certifications 2

SDS No.: 283259 V004.0
LOCTITE LB 8192 known as Loctite 8192
Page 10 of 15
Germ cell mutagenicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
Propan-2-ol
67-63-0
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
equivalent or similar to OECD
Guideline 471 (Bacterial
Reverse Mutation Assay)
Propan-2-ol
67-63-0
negative
mammalian cell
gene mutation assay
with and without
equivalent or similar to OECD
Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)
Butane, n- (< 0.1 %
butadiene)
106-97-8
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Butane, n- (< 0.1 %
butadiene)
106-97-8
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Propane
74-98-6
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Propane
74-98-6
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Isobutane
75-28-5
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Isobutane
75-28-5
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Propan-2-ol
67-63-0
negative
intraperitoneal
mouse
equivalent or similar to OECD
Guideline 474 (Mammalian
Erythrocyte Micronucleus
Test)
Butane, n- (< 0.1 %
butadiene)
106-97-8
negative
Drosophila
melanogaster
not specified
Butane, n- (< 0.1 %
butadiene)
106-97-8
negative
inhalation: gas
rat
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
Propane
74-98-6
negative
Drosophila
melanogaster
not specified
Propane
74-98-6
negative
inhalation: gas
rat
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
Isobutane
75-28-5
negative
Drosophila
melanogaster
not specified
Isobutane
75-28-5
negative
inhalation: gas
rat
OECD Guideline 474
(Mammalian Erythrocyte
Micronucleus Test)
Carcinogenicity
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous components
CAS-No.
Result
Route of
application
Exposure
time /
Frequency
of treatment
Species
Sex
Method
Propan-2-ol
67-63-0
inhalation:
vapour
104 w
6 h/d, 5 d/w
rat
male/female
OECD Guideline 451
(Carcinogenicity
Studies)