Certifications 2

SDS No.: 153555 V002.0
LOCTITE 406/770 TAK PAK
Page 9 of 15
Acute inhalative toxicity:
The mixture is classified based on calculation method referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Value
type
Value
Test atmosphere
Exposure
time
Species
Method
n-Heptane
142-82-5
LC50
> 29,29 mg/l
vapour
4 h
rat
OECD Guideline 403 (Acute
Inhalation Toxicity)
Methylcyclohexane
108-87-2
LC50
> 26,3 mg/l
vapour
1 h
rat
not specified
Skin corrosion/irritation:
The mixture is classified based on calculation method referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Exposure
time
Species
Method
n-Heptane
142-82-5
irritating
rabbit
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Methylcyclohexane
108-87-2
not irritating
24 h
rabbit
Draize Test
Serious eye damage/irritation:
The mixture is classified based on calculation method referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Exposure
time
Species
Method
n-Heptane
142-82-5
not irritating
rabbit
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Methylcyclohexane
108-87-2
not irritating
rabbit
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Respiratory or skin sensitization:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Test type
Species
Method
n-Heptane
142-82-5
not sensitising
Guinea pig maximisation
test
guinea pig
OECD Guideline 406 (Skin Sensitisation)
Methylcyclohexane
108-87-2
not sensitising
Buehler test
guinea pig
OECD Guideline 406 (Skin Sensitisation)
Germ cell mutagenicity:
The mixture is classified based on threshold limits referring to the classified substances present in the mixture.
Hazardous substances
CAS-No.
Result
Type of study /
Route of
administration
Metabolic
activation /
Exposure time
Species
Method
n-Heptane
142-82-5
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
n-Heptane
142-82-5
negative
in vitro mammalian
chromosome
aberration test
not applicable
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Methylcyclohexane
108-87-2
negative
bacterial reverse
mutation assay (e.g
Ames test)
with and without
OECD Guideline 471
(Bacterial Reverse Mutation
Assay)
Methylcyclohexane
108-87-2
negative
in vitro mammalian
chromosome
aberration test
with and without
OECD Guideline 473 (In vitro
Mammalian Chromosome
Aberration Test)
Methylcyclohexane
108-87-2
negative
mammalian cell
gene mutation assay
with and without
OECD Guideline 476 (In vitro
Mammalian Cell Gene
Mutation Test)