User guide

Chapter 3: Getting Started
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12
Chemical Resistance of Freeze Dryer
Components
The FreeZone Freeze Dry System is designed to be chemically resistant to
most compounds that are commonly used in freeze drying processes.
However, by necessity, the freeze dryer is comprised of a number of different
materials, some of which may be attacked and degraded by certain chemicals.
The degree of degradation is dependent on the concentration and exposure
duration. Some of the major components of the FreeZone Freeze Dry System
that are susceptible to degradation are as follows:
Acids
Buffers
Solvents
Component
Material
Acetic Acid 20%
Formic Acid
Trifluoroacetic Acid (TFA)
Calcium Chloride
Sodium Phosphate
Acetone
Acetonittirle
Carbon Tetrochloride
Cyclohexane
Dioxane
Methyl t-Butyl Ether (BTBE)
Pyridine
Valve Stem
Acetal
C
D
D
D
D
Collector Lid
Acrylic
D
D
D
D
Hoses, Gaskets
& Valve
Bodies
Neoprene
C
D
D
C
C
D
D
D
C
D
Flask Top
Silicon Rubber
C
D
D
D
D
D
C
D
Chamber &
Fittings
Stainless Steel
C
C – Moderate degradation; Limited use
D – Severe degradation; infrequent use recommended; immediate thorough
cleaning required.
 Most common compounds used in freeze drying processes, if allowed to
enter the vacuum pump, will degrade the oil and cause damage to the
vacuum pump.
 Sugars and proteins typically will have minimal negative effect on any of
the materials of construction.
When using compounds in the freeze dryer that are hostile to the materials of
construction, it is imperative the equipment is thoroughly cleaned after use.
 Rubber and plastic components that have been exposed to damaging
compounds should be removed and flushed with water.