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3017FR DuPont Page 6
Material Safety Data Sheet
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TOXICOLOGICAL INFORMATION
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Animal Data
Inhalation 4-hour LC50: >663,000 ppm in rats
HFC-23 is untested for skin and eye irritancy, and for
animal sensitization.
Effects from single high inhalation exposure to HFC-23
include anaesthetic effects, and nonspecific effects such as
weight loss were observed at concentrations >22%. No
cardiac sensitization was observed in dogs after breathing
800,000 ppm for periods of 5-10 minutes following
epinephrine challenge. In another test, dogs exposed to up
to 30% or up to 50% (with aditional oxygen), had no positive
responses. No cardiac sensitization occurred in baboons
exposed by inhalation to 10%, 30%, 50%, or 70% HFC-23 before
or after an epinephrine challenge; there was a dose-related
decrease in heart rates and differences in respiratory rates
during exposure.
No animal tests are available to define the carcinogenic
hazards of HFC-23. The maternal and developmental NOAEL was
50,000 ppm. HFC-23 is not considered a unique developmental
hazard to the conceptus. There were no developmental or
reproductive effects.
Tests have shown that HFC-23 does not produce genetic damage
in bacterial or mammalian cell cultures. It has not
produced genetic damage in tests on animals.
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Reclaim by distillation or remove to permitted waste
facility. Dispose of in accordance with all Federal, State,
and local regulations.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT/IMO/IATA
Proper Shipping Name : Trifluoromethane
Hazard Class : 2.2
UN No. : 1984
DOT/IMO Label : Nonflammable Gas