Use Instructions

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Table 14: Baseline Medications: ITT Population
FIX-HF-5C2
FIX-HF-5C
Variable
OPTIMIZER
OPTIMIZER
P-value
1
Control
P-value
1
ACEi/ARB/ARNi
45 (75.0%)
61 (82.4%)
0.393
72 (83.7%)
0.212
ACE inhibitor
29 (48.3%)
40 (54.1%)
0.603
49 (57.0%)
0.317
ARB
8 (13.3%)
18 (24.3%)
0.128
22 (25.6%)
0.096
ARNi
9 (15.0%)
3 (4.1%)
0.035
3 (3.5%)
0.028
Beta Blocker
57 (95.0%)
72 (97.3%)
0.656
82 (95.3%)
1.000
Diuretic
44 (73.3%)
57 (77.0%)
0.689
67 (77.9%)
0.558
Secondary Diuretic
5 (8.3%)
6 (8.1%)
1.000
8 (9.3%)
1.000
Ivabradine
3 (5.0%)
2 (2.7%)
0.656
4 (4.7%)
1.000
Digoxin
4 (6.7%)
10 (13.5%)
0.260
8 (9.3%)
0.762
Aldosterone Inhibitor
25 (41.7%)
26 (35.1%)
0.477
33 (38.4%)
0.733
Hydralazine
3 (5.0%)
5 (6.8%)
0.731
10 (11.6%)
0.240
Nitrates
11 (18.3%)
18 (24.3%)
0.527
26 (30.2%)
0.124
Calcium Channel Blocker
6 (10.0%)
9 (12.2%)
0.787
8 (9.3%)
1.000
Anti-arrhythmic
19 (31.7%)
14 (18.9%)
0.108
12 (14.0%)
0.013
Anti-platelet
41 (68.3%)
54 (73.0%)
0.572
59 (68.6%)
1.000
Anticoagulant
27 (45.0%)
19 (25.7%)
0.028
18 (20.9%)
0.003
1
Compared to FIX-HF-5C2 OPTIMIZER Group via Fishers exact test.