MSDS

Product Name:
GREAT STUFF(TM) Window and Door Insulating
Foam Sealant 16oz HC ES
Issue Date:
12/10/2012
Page
7 of 13
Ingestion
As product: Single dose oral LD50 has not been determined.
Estimated. LD50, rat > 2,000 mg/kg
Dermal
As product: The dermal LD50 has not been determined.
Estimated. LD50, rabbit > 2,000 mg/kg
Inhalation
As product: The LC50 has not been determined.
Eye damage/eye irritation
May cause eye irritation. May cause slight temporary corneal injury.
Skin corrosion/irritation
Prolonged contact may cause moderate skin irritation with local redness. Material may stick to skin
causing irritation upon removal. May stain skin.
Sensitization
Skin
Skin contact may cause an allergic skin reaction. Animal studies have shown that skin contact with
isocyanates may play a role in respiratory sensitization.
Respiratory
May cause allergic respiratory response. MDI concentrations below the exposure guidelines may
cause allergic respiratory reactions in individuals already sensitized. Asthma-like symptoms may
include coughing, difficult breathing and a feeling of tightness in the chest. Occasionally, breathing
difficulties may be life threatening.
Repeated Dose Toxicity
Tissue injury in the upper respiratory tract and lungs has been observed in laboratory animals after
repeated excessive exposures to MDI/polymeric MDI aerosols.
Chronic Toxicity and Carcinogenicity
Lung tumors have been observed in laboratory animals exposed to respirable aerosol droplets of
MDI/Polymeric MDI (6 mg/m3) for their lifetime. Tumors occurred concurrently with respiratory
irritation and lung injury. Current exposure guidelines are expected to protect against these effects
reported for MDI.
Developmental Toxicity
In laboratory animals, MDI/polymeric MDI did not cause birth defects; other fetal effects occurred only
at high doses which were toxic to the mother.
Reproductive Toxicity
No relevant data found.
Genetic Toxicology
In vitro genetic toxicity studies were negative for component(s) tested. Genetic toxicity data on MDI
are inconclusive. MDI was weakly positive in some in vitro studies; other in vitro studies were negative.
Animal mutagenicity studies were predominantly negative.
12. Ecological Information
Toxicity
Data for Component: Polymethylenepolyphenyl polyisocyanate, polypropyleneglycol copolymer
Not expected to be acutely toxic to aquatic organisms.
Data for Component: Isocyanic acid, polymethylenepolyphenylene ester, polymer with
.alpha.,.alpha.',.alpha.''-1,2,3-propanetriyltris[.omega.-hydroxypoly
Not expected to be acutely toxic to aquatic organisms.
Data for Component: Diphenylmethane Diisocyanate, isomers and homologues
The measured ecotoxicity is that of the hydrolyzed product, generally under conditions
maximizing production of soluble species. Material is practically non-toxic to aquatic
organisms on an acute basis (LC50/EC50/EL50/LL50 >100 mg/L in the most sensitive species
tested).
Fish Acute & Prolonged Toxicity