User guide
M
Millenium™ RO System by GE Osmonics 
14693e - 31 Mar 03  4- 23  Routine Maintenance 
4.4.2.1 Renalin® Pre-Disinfection Preparation 
CAUTION: 
When ‘RENALIN®’ is to be used as a disinfectant, several preparatory steps are 
required by GE Osmonics as well as the membrane manufacturer. Failure to 
comply with these instructions, which incorporate instructions from the membrane 
manufacturer, will jeopardize the system performance and warranty. 
a.  The system must be free of all incompatible materials. 
b.  Clean the membranes with an acid such as 0.1% HCl or 0.4% phosphoric 
acids. Calcium and Iron Cleaner may be used as an alternate. It is essential 
that all iron and other transition metals be removed from the membrane 
surface. 
CAUTION: 
The RO system must be disconnected from the tempered water source (if present). 
The solution temperature must be monitored closely. At temperatures above 25° 
the ‘RENALIN®’ solution becomes very aggressive towards the RO membranes 
and will damage them in a short period of time. The disinfection procedure will 
raise the temperature of the solution. The operator must be prepared to add ice to 
the solution or discontinue the procedure when the water temperature approaches 
77ºF /25°C. 
1.  Read and understand the ‘RENALIN®’ disinfection procedure. Pay particular 
attention to steps a and b in CAUTION statement above before initiating the 
procedure. 
2.  Ensure the cleaning/disinfectant container is clean. Add two gallons (7.6 liters) of 
RO permeate (product water) to the container. 
3.  Add 2.6 ounces (80 milliliters) of disinfectant concentrate to the container and 
mix to prepare a 1:100 (1%) dilution. 
WARNING: 
Label the machine with appropriate warning signs such as "Do Not Use/ Contains 
Disinfectant” to prevent use of the RO until properly rinsed. 
4.  Disconnect the dialysis machine from the RO product port and install the product 
rinse line. Place the open end in the disinfectant solution container and ensure the 
product valve is open. 
5.  Attach the quick-disconnect end of the disinfect line to the disinfect port of the 
RO. Put the open end of the disinfect line in the disinfectant. 
6.  Disconnect the waste line from the drain connection and place the open end in the 
disinfectant solution container. 










