SDS
HD012A 24C(T)
Page:11/14
Version:
1.3
Date of issue/Date of revision:
09/30/2015
Date of previous issue:
07/31/2015
exposed to D4 by inhalation, data showed a statistically significant increase in a benign uterine tumor in female
rats exposed at the highest level--a level much higher than the low levels that consumers or workers may
encounter. An expert panel of independent scientists who have reviewed the results of this research concur that
the finding seen in the two-year study occurred through a biological pathway that is specific to the rat and is not
relevant to humans. Therefore, this observed effect does not indicate a potential health hazard to humans. In
developmental toxicity studies, rats and rabbits were exposed to D4 at concentrations up to 700 ppm and 500
ppm, respectively. No teratogenic effects (birth defects) were observed in either study.
Section 12. Ecological information
Ecotoxicity
Conclusion/Summary
:
Not available
Persistence/degradability
Product/ingredient
name
Test
Result
Dose
Inoculum
octamethylcyclotetrasil
oxane
310 Ready
Biodegradability
- CO₂ in Sealed
Vessels
(Headspace Test)
3.7 % - 29 d
Activated sludge
Remarks:
Not readily biodegradable.
Conclusion/Summary
:
Not available
Bioaccumulative potential
Product/ingredient name
Species
Exposure
LogPow
BCF
Potential
Octamethylcyclotetrasiloxane
Fathead
minnow
28 d
12.40
low
Mobility in soil
Soil/water partition coefficient
(KOC)
:
Not available
Other adverse effects
:
No known significant effects or critical hazards.
Other information
Octamethylcyclotetrasiloxane (D4) meets the current REACh Annex XIII criteria for PBT and vPvB. However,
D4 does not behave similarly to known PBT/vPvB substances. The silicones industries interpretation of the
available data is that the weight of scientific evidence from field studies shows that D4 is not biomagnifying in
aquatic and terrestrial food webs. D4 in air will degrade by reaction with naturally occurring hydroxyl radicals
in the atmosphere. Any D4 in air that does not degrade by reaction with hydroxyl radicals is not expected to
deposit from the air to water, to land, or to living organisms.
Section 13. Disposal considerations
Disposal methods
:
The generation of waste should be avoided or minimized wherever
possible. Disposal of this product, solutions and any by-products