SDS

HD012A 24C(T)
Page:10/14
Version:
1.3
Date of issue/Date of revision:
09/30/2015
Date of previous issue:
07/31/2015
skeletal malformations
Delayed and immediate effects and also chronic effects from short and long term exposure
Short term exposure
Potential immediate effects
:
Not available
Potential delayed effects
:
Not available
Long term exposure
Potential immediate effects
:
Not available
Potential delayed effects
:
Not available
Potential chronic health effects
Product/ingredient name
Result
Species
Dose
Exposure
Octamethylcyclotetrasiloxa
ne
NOAEC
Inhalation
Rat
150 mg/kg
OECD 453
24 months
Remarks:
NOAEC
NOAEL
Dermal
Rabbit
> 1 mg/kg
OECD 410
3 weeks
Remarks:
NOAEL
Conclusion/Summary
:
Not determined
General
:
No known significant effects or critical hazards.
Carcinogenicity
:
No known significant effects or critical hazards.
Mutagenicity
:
No known significant effects or critical hazards.
Teratogenicity
:
No known significant effects or critical hazards.
Developmental effects
:
No known significant effects or critical hazards.
Fertility effects
:
Suspected of damaging fertility.
Numerical measures of toxicity
Acute toxicity estimates
Route
ATE value
Oral
14,591.8 mg/kg
Other information
Octamethylcyclotetrasiloxane (D4) Ingestion: Rodents given large doses via oral gavage of
Octamethylcyclotetrasiloxane (1600mg/kg/day,14 days), developed increased liver weights relative to
unexposed control animals due to hepatocellular hyperplasia (increased number of liver cells which appear
normal) as well as hypertrophy (increased cell size). Inhalation: In inhalation studies, laboratory rodents
exposed to Octamethylcyclotetrasiloxane (300 ppm five days/week, 90 days) developed increased liver weights
in female animals relative to unexposed control animals. When the exposure was stopped, liver weights
returned to normal. Microscopic examination of the liver cells did not show any evidence of pathology. This
response in rats, which does not affect the animal's health, is well-documented and widely recognized. It is
related to an increase of liver enzymes that metabolize and eliminate a material from the body. The increased
liver weight reverses even while the D4 exposure continues. The finding is not adverse, but is considered a
natural adaptive change in rats, and does not represent a hazard to humans. Inhalation studies utilizing
laboratory rabbits and guinea pigs showed no effects on liver weights. Inhalation exposures typical of industrial
usage (5-10 ppm) showed no toxic effects in rodents. Range finding reproductive studies were conducted
(whole body inhalation, 70 days prior to mating, through mating, gestation and lactation), with D4. Rats were
exposed to 70 and 700 ppm. In the 700 ppm group, there was a statistically significant reduction in mean litter
size and in implantation sites. No D4 related clinical signs were observed in the pups and no exposure related
pathological findings were found. A two-year, combined chronic/carcinogenicity study, during which rats were